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UF Health University of Florida

Institute on Aging
Department of Aging & Geriatric Research

College of Medicine

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Todd Manini

Todd Manini, Ph.D.

Professor; Chief, Division Of EDGE

Department: MD-AGING-CLINICAL RESEARCH
Business Phone: (352) 273-5914
Business Email: tmanini@ufl.edu
CV: View Curriculum Vitae

About Todd Manini

A native of Wintersville, Ohio, Dr. Manini attended Ohio University in Athens, OH where he graduated with honors in Biology, Exercise Science, and Biochemistry. He received his M.S. and Ph.D. as well as a Certificate of Advanced Studies in Gerontology from Syracuse University. He completed a fellowship at the Laboratory of Epidemiology, Demography and Biometry at the National Institute on Aging at the National Institutes of Health in Bethesda, MD. He is now a Tenured Associate Professor at the University of Florida (UF) in the Department of Aging and Geriatric Research. He is the Leader of the Data Science and Applied Technology Core in the UF Claude D. Pepper Older American’s Independence Center. The Core is designed to maintain pace in a world that is becoming a connected system of computing and sensing components for mobility tracking in older adults. (mHealth). At an international level, he has fellow status at two societies: The American College of Sports Medicine and The Gerontological Society of America. He is the Chair of the American College of Sports Medicine Strategic Health Initiative on Aging and he carried this leadership to the Gerontological Society of America where he is the Co-Chair of the Measurement, Statistics, and Research Design (MSRD) Interest Group. He was also honored with being a standing member on NIH’s Center for Scientific Review as part of the Neurological, Aging and Musculoskeletal Epidemiology (NAME) Study Section. Lastly, he serves on the editorial board of the Journals of Gerontology: Medical Sciences. He is an active mentor and teacher by being awarded in 2011 with the UF College of Medicine Exemplary Teachers Award. He has also recently completed the 2018 Mentor Academy professional development program that develops the next generation of clinical and translational scientists through a culture of support for mentoring and training. He graduated from the inaugural class of the CTSI’s Academy of Research Excellence His current areas of research include: 1) developing and conducting randomized interventions to combat losses in physical performance seen with aging, 2) understanding the degree to which aging modifies the metabolic cost of performing daily activities, 3) identifying the role that mitochondria have in explaining cardiovascular responsiveness to chronic physical activity and 4) developing wearable technology (e.g. smart watch) for scalable ascertainment of real-time, free-living activity and community mobility in older adults. He receives support from the National Institute on Aging, American Heart Association, The National Heart, Lung and Blood Institute, and National Cancer Institute for his work.

Publications

2020
Application of Cut-Points for Low Muscle Strength and Lean Mass in Mobility-Limited Older Adults.
Journal of the American Geriatrics Society
2020
Transcutaneous Electrical Stimulation on the Submental Area: The Relations of Biopsychological Factors with Maximum Amplitude Tolerance and Perceived Discomfort Level.
Dysphagia
2020
Trajectories of Short Physical Performance Battery Are Strongly Associated with Future Major Mobility Disability: Results from the LIFE Study.
Journal of clinical medicine
2020
Three-year post-intervention follow-up comparison of healthcare resource utilization and costs in the Lifestyle Interventions and Independence for Elders (LIFE) Study.
The journals of gerontology. Series A, Biological sciences and medical sciences
2020
Secondary care provider attitudes towards patient generated health data from smartwatches.
NPJ digital medicine
2020
Sarcopenia Definition: The Position Statements of the Sarcopenia Definition and Outcomes Consortium.
Journal of the American Geriatrics Society
2020
Sarcopenia Definition & Outcomes Consortium Defined Low Grip Strength in Two Cross-Sectional, Population-Based Cohorts.
Journal of the American Geriatrics Society
2020
Relative contribution of muscle strength, lean mass, and lower extremity motor function in explaining between-person variance in mobility in older adults.
BMC geriatrics
2020
Reduced neural excitability and activation contribute to clinically-meaningful weakness in older adults.
The journals of gerontology. Series A, Biological sciences and medical sciences
2020
Putative Cut-Points in Sarcopenia Components and Incident Adverse Health Outcomes: An SDOC Analysis.
Journal of the American Geriatrics Society
2020
Impact of Baseline Fatigue on a Physical Activity Intervention to Prevent Mobility Disability.
Journal of the American Geriatrics Society
2020
Impact of Anticholinergic Medication Burden on Mobility and Falls in the Lifestyle Interventions for Elders (LIFE) Study.
Journal of clinical medicine
2020
Impact and Lessons From the Lifestyle Interventions and Independence for Elders (LIFE) Clinical Trials of Physical Activity to Prevent Mobility Disability.
Journal of the American Geriatrics Society
2020
Application of SDOC Cut Points for Low Muscle Strength for Recovery of Walking Speed After Hip Fracture.
The journals of gerontology. Series A, Biological sciences and medical sciences
2020
Higher dose of resveratrol elevated cardiovascular disease risk biomarker levels in overweight older adults – A pilot study.
Experimental gerontology
2020
Application of Selected Muscle Strength and Body Mass Cut Points for the Diagnosis of Sarcopenia in Men and Women With or at Risk for HIV Infection.
The journals of gerontology. Series A, Biological sciences and medical sciences
2020
Association of Fish Oil and Physical Activity on Mobility Disability in Older Adults.
Medicine and science in sports and exercise
2020
Comparative Effects of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers on Response to a Physical Activity Intervention in Older Adults: Results From the Lifestyle Interventions and Independence for Elders Study.
The journals of gerontology. Series A, Biological sciences and medical sciences
2020
Comparison of a Multi-Component Physical Function Battery to Usual Walking Speed for Assessing Lower Extremity Function and Mobility Limitation in Older Adults.
The journal of nutrition, health & aging
2020
Corrigendum: Multimodal Imaging of Brain Activity to Investigate Walking and Mobility Decline in Older Adults (Mind in Motion Study): Hypothesis, Theory, and Methods.
Frontiers in aging neuroscience
2020
Identification of Sarcopenia Components That Discriminate Slow Walking Speed: A Pooled Data Analysis.
Journal of the American Geriatrics Society
2020
Establishing the Link Between Lean Mass and Grip Strength Cut Points With Mobility Disability and Other Health Outcomes: Proceedings of the Sarcopenia Definition and Outcomes Consortium Conference.
The journals of gerontology. Series A, Biological sciences and medical sciences
2020
Evaluation of the Potential Acetylcholinesterase Inhibitor-Induced Rhinorrhea Prescribing Cascade.
Journal of the American Geriatrics Society
2020
Healthcare Utilization and Physical Functioning in Older Adults in the United States.
Journal of the American Geriatrics Society
2020
Effect of a Multifactorial Fall Injury Prevention Intervention on Patient Well-Being: The STRIDE Study
Journal of the American Geriatrics Society
2019
Multimodal Imaging of Brain Activity to Investigate Walking and Mobility Decline in Older Adults (Mind in Motion Study): Hypothesis, Theory, and Methods.
Frontiers in aging neuroscience
2019
Wearable Technology To Reduce Sedentary Behavior And CVD Risk In Older Adults: A Pilot Randomized Clinical Trial.
Clinical interventions in aging
2019
Voluntary vs Electrically Stimulated Activation in Age-Related Muscle Weakness.
JAMA network open
2019
Translating the Lifestyle Interventions and Independence for Elders Clinical Trial to Older Adults in a Real-World Community-Based Setting.
The journals of gerontology. Series A, Biological sciences and medical sciences
2019
The Enabling Reduction of Low-Grade Inflammation in Seniors (ENRGISE) Pilot Study: Screening Methods and Recruitment Results.
The journals of gerontology. Series A, Biological sciences and medical sciences
2019
The Effects of Time Restricted Feeding on Overweight, Older Adults: A Pilot Study.
Nutrients
2019
The Effects of Electrical Stimulation Pulse Duration on Lingual Palatal Pressure Measures During Swallowing in Healthy Older Adults.
Dysphagia
2019
Role of Wearable Accelerometer Devices in Delirium Studies: A Systematic Review.
Critical care explorations
2019
Perception of Older Adults Toward Smartwatch Technology for Assessing Pain and Related Patient-Reported Outcomes: Pilot Study.
JMIR mHealth and uHealth
2019
Movement-evoked pain: transforming the way we understand and measure pain.
Pain
2019
Mitochondrial DNA variants and pulmonary function in older persons.
Experimental gerontology
2019
Magnitude of and Characteristics Associated With the Treatment of Calcium Channel Blocker-Induced Lower-Extremity Edema With Loop Diuretics.
JAMA network open
2019
A comparison of accelerometry analysis methods for physical activity in older adult women and associations with health outcomes over time.
Journal of sports sciences
2019
A smartwatch-based framework for real-time and online assessment and mobility monitoring.
Journal of biomedical informatics
2019
Accuracy of Samsung Gear S Smartwatch for Activity Recognition: Validation Study.
JMIR mHealth and uHealth
2019
Advanced Age Is Associated with Iron Dyshomeostasis and Mitochondrial DNA Damage in Human Skeletal Muscle.
Cells
2019
Blood Flow-restricted Exercise Does Not Induce a Cross-Transfer of Effect: A Randomized Controlled Trial.
Medicine and science in sports and exercise
2019
A Case for Promoting Movement Medicine: Preventing Disability in the LIFE Randomized Controlled Trial.
The journals of gerontology. Series A, Biological sciences and medical sciences
2019
Effect of Gastric Acid Suppressants on Response to a Physical Activity Intervention and Major Mobility Disability in Older Adults: Results from the Lifestyle Interventions for Elders (LIFE) Study.
Pharmacotherapy
2019
Effect of Hospitalizations on Physical Activity Patterns in Mobility-Limited Older Adults.
Journal of the American Geriatrics Society
2019
Effect of Losartan and Fish Oil on Plasma IL-6 and Mobility in Older Persons. The ENRGISE Pilot Randomized Clinical Trial.
The journals of gerontology. Series A, Biological sciences and medical sciences
2019
Blood-Flow Restriction Resistance Exercise for Older Adults with Knee Osteoarthritis: A Pilot Randomized Clinical Trial.
Journal of clinical medicine
2018
Gait Speed and Mobility Disability: Revisiting Meaningful Levels in Diverse Clinical Populations.
Journal of the American Geriatrics Society
2018
Wrist accelerometer shape feature derivation methods for assessing activities of daily living.
BMC medical informatics and decision making
2018
The Influence of Physical Activity and Sedentary Behavior on Living to Age 85 Years Without Disease and Disability in Older Women.
The journals of gerontology. Series A, Biological sciences and medical sciences
2018
Social Participation Modifies the Effect of a Structured Physical Activity Program on Major Mobility Disability Among Older Adults: Results From the LIFE Study.
The journals of gerontology. Series B, Psychological sciences and social sciences
2018
Self-Reported Physical Function As a Predictor of Hospitalization in the Lifestyle Interventions and Independence for Elders Study.
Journal of the American Geriatrics Society
2018
Mitochondrial DNA Sequence Variants Associated With Blood Pressure Among 2 Cohorts of Older Adults.
Journal of the American Heart Association
2018
Mitochondrial DNA m.3243A > G heteroplasmy affects multiple aging phenotypes and risk of mortality.
Scientific reports
2018
Mitochondrial DNA m.13514G>A heteroplasmy is associated with depressive symptoms in the elderly.
International journal of geriatric psychiatry
2018
Meta-analysis identifies mitochondrial DNA sequence variants associated with walking speed.
GeroScience
2018
Maintenance of Physical Function 1 Year After Exercise Intervention in At-Risk Older Adults: Follow-up From the LIFE Study.
The journals of gerontology. Series A, Biological sciences and medical sciences
2018
Evidence-based nutritional and pharmacological interventions targeting chronic low-grade inflammation in middle-age and older adults: A systematic review and meta-analysis.
Ageing research reviews
2018
Transition Icons for Time-Series Visualization and Exploratory Analysis.
IEEE journal of biomedical and health informatics
2018
Effects of 90 Days of Resveratrol Supplementation on Cognitive Function in Elders: A Pilot Study.
Journal of alternative and complementary medicine (New York, N.Y.)
2018
Effect of Physical Activity on Frailty: Secondary Analysis of a Randomized Controlled Trial.
Annals of internal medicine
2018
Effect of 24-month physical activity on cognitive frailty and the role of inflammation: the LIFE randomized clinical trial.
BMC medicine
2018
Dopamine-Related Genotypes and Physical Activity Change During an Intervention: The Lifestyle Interventions and Independence for Elders Study.
Journal of the American Geriatrics Society
2018
Diet and Activity Assessments and Interventions Using Technology in Older Adults.
American journal of preventive medicine
2018
Community-Based Activity and Sedentary Patterns Are Associated With Cognitive Performance in Mobility-Limited Older Adults.
Frontiers in aging neuroscience
2018
Comment on: “Pitfalls in the measurement of muscle mass: a need for a reference standard” by Buckinx et al.
Journal of cachexia, sarcopenia and muscle
2018
Associations between ACE-Inhibitors, Angiotensin Receptor Blockers, and Lean Body Mass in Community Dwelling Older Women.
Journal of aging research
2018
A Comparison of Self-report Indices of Major Mobility Disability to Failure on the 400-m Walk Test: The LIFE Study.
The journals of gerontology. Series A, Biological sciences and medical sciences
2018
Activity and Circadian Rhythm of Sepsis Patients in the Intensive Care Unit.
… IEEE-EMBS International Conference on Biomedical and Health Informatics. IEEE-EMBS International Conference on Biomedical and Health Informatics
2018
Evaluating Accelerometry Thresholds for Detecting Changes in Levels of Moderate Physical Activity and Resulting Major Mobility Disability.
The journals of gerontology. Series A, Biological sciences and medical sciences
2017
Leisure-time physical activity and leukocyte telomere length among older women.
Experimental gerontology
2017
Impact of chemotherapy on medium-term physical function and activity of older breast cancer survivors, and associated biomarkers.
Journal of geriatric oncology
2017
Effects of Popular Diets without Specific Calorie Targets on Weight Loss Outcomes: Systematic Review of Findings from Clinical Trials.
Nutrients
2017
ENabling Reduction of Low-grade Inflammation in SEniors Pilot Study: Concept, Rationale, and Design.
Journal of the American Geriatrics Society
2017
Metabolic costs of daily activity in older adults (Chores XL) study: design and methods.
Contemporary clinical trials communications
2017
Exercise’s effect on mobility disability in older adults with and without obesity: The LIFE study randomized clinical trial.
Obesity (Silver Spring, Md.)
2017
Osteoporosis in the Women’s Health Initiative: Another Treatment Gap?
The American journal of medicine
2017
Systemic inflammation, body composition, and physical performance in old community-dwellers.
Journal of cachexia, sarcopenia and muscle
2017
Prognostic Value of Braden Activity Subscale for Mobility Status in Hospitalized Older Adults.
Journal of hospital medicine
2017
Surveying predictors of late-life longitudinal change in daily activity energy expenditure.
PloS one
2017
Effects of blood-flow restriction on biomarkers of myogenesis in response to resistance exercise.
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme
2017
The Need for Standardized Assessment of Muscle Quality in Skeletal Muscle Function Deficit and Other Aging-Related Muscle Dysfunctions: A Symposium Report.
Frontiers in physiology
2017
Wearable technology to reduce sedentary behavior and CVD risk in older adults: design of a randomized controlled trial.
Contemporary clinical trials communications
2017
Predictors of Change in Physical Function in Older Adults in Response to Long-Term, Structured Physical Activity: The LIFE Study.
Archives of physical medicine and rehabilitation
2017
Effects of a Long-Term Physical Activity Program on Activity Patterns in Older Adults.
Medicine and science in sports and exercise
2017
The effect of intervening hospitalizations on the benefit of structured physical activity in promoting independent mobility among community-living older persons: secondary analysis of a randomized controlled trial.
BMC medicine
2017
Effect of Physical Activity on Self-Reported Disability in Older Adults: Results from the LIFE Study.
Journal of the American Geriatrics Society
2017
Effect of Physical Activity versus Health Education on Physical Function, Grip Strength and Mobility.
Journal of the American Geriatrics Society
2017
A New Adaptive Home-based Exercise Technology among Older Adults Living in Nursing Home: A Pilot Study on Feasibility, Acceptability and Physical Performance.
The journal of nutrition, health & aging
2017
A new approach to disentangle genetic and epigenetic components on disease comorbidities: studying correlation between genotypic and phenotypic disease networks.
Procedia computer science
2017
Association between age-related reductions in testosterone and risk of prostate cancer-An analysis of patients’ data with prostatic diseases.
International journal of cancer
2017
Association Between Structured Physical Activity and Sedentary Time in Older Adults.
JAMA
2017
Association of Accelerometer-Measured Physical Activity With Leukocyte Telomere Length Among Older Women.
The journals of gerontology. Series A, Biological sciences and medical sciences
2017
Associations of Accelerometer-Measured and Self-Reported Sedentary Time With Leukocyte Telomere Length in Older Women.
American journal of epidemiology
2017
Association of Accelerometry-Measured Physical Activity and Cardiovascular Events in Mobility-Limited Older Adults: The LIFE (Lifestyle Interventions and Independence for Elders) Study.
Journal of the American Heart Association
2017
Can KAATSU Exercise Cause Rhabdomyolysis?
Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine
2017
Change in Physical Activity and Sitting Time After Myocardial Infarction and Mortality Among Postmenopausal Women in the Women’s Health Initiative-Observational Study.
Journal of the American Heart Association
2017
Device-Measured Physical Activity As a Predictor of Disability in Mobility-Limited Older Adults.
Journal of the American Geriatrics Society
2017
Dose of physical activity, physical functioning and disability risk in mobility-limited older adults: Results from the LIFE study randomized trial.
PloS one
2017
Blood flow restricted resistance training in older adults at risk of mobility limitations.
Experimental gerontology
2017
Dynapenia and Metabolic Health in Obese and Nonobese Adults Aged 70 Years and Older: The LIFE Study.
Journal of the American Medical Directors Association
2016
Using symbolic aggregate approximation (SAX) to visualize activity transitions among older adults.
Physiological measurement
2016
Physical impairment and body weight history in postmenopausal women: the Women’s Health Initiative.
Public health nutrition
2016
Metabolic Rate and Perceived Exertion of Walking in Older Adults With Idiopathic Chronic Fatigue.
The journals of gerontology. Series A, Biological sciences and medical sciences
2016
Long-Term Cigarette Smoking Trajectories Among HIV-Seropositive and Seronegative MSM in the Multicenter AIDS Cohort Study.
AIDS and behavior
2016
Letter to the editor: results from a Web-based survey to identify dynapenia screening tools and risk factors.
Journal of cachexia, sarcopenia and muscle
2016
Idiopathic chronic fatigue in older adults is linked to impaired mitochondrial content and biogenesis signaling in skeletal muscle.
Oncotarget
2016
Hospitalizations During a Physical Activity Intervention in Older Adults at Risk of Mobility Disability: Analyses from the Lifestyle Interventions and Independence for Elders Randomized Clinical Trial.
Journal of the American Geriatrics Society
2016
Socioeconomic differences in the benefits of structured physical activity compared with health education on the prevention of major mobility disability in older adults: the LIFE study.
Journal of epidemiology and community health
2016
Evaluating Walking Intensity with Hip-Worn Accelerometers in Elders.
Medicine and science in sports and exercise
2016
Genetic Moderators of the Impact of Physical Activity on Depressive Symptoms.
The Journal of frailty & aging
2016
Actigraphy features for predicting mobility disability in older adults.
Physiological measurement
2016
Analysis and Interpretation of Accelerometry Data in Older Adults: The LIFE Study.
The journals of gerontology. Series A, Biological sciences and medical sciences
2016
Anticholinergic Drug Use and Risk to Cognitive Performance in Older Adults with Questionable Cognitive Impairment: A Cross-Sectional Analysis.
Drugs & aging
2016
In-Hospital Mobility Variations Across Primary Diagnoses Among Older Adults.
Journal of the American Medical Directors Association
2016
Depressive symptom severity is associated with increased cortical thickness in older adults.
International journal of geriatric psychiatry
2016
Effectiveness of blood flow restricted exercise compared with standard exercise in patients with recurrent low back pain: study protocol for a randomized controlled trial.
Trials
2016
Cost-effectiveness of the LIFE Physical Activity Intervention for Older Adults at Increased Risk for Mobility Disability.
The journals of gerontology. Series A, Biological sciences and medical sciences
2015
Using physical activity to gain the most public health bang for the buck.
JAMA internal medicine
2015
The MAT-sf: identifying risk for major mobility disability.
The journals of gerontology. Series A, Biological sciences and medical sciences
2015
Successful aging: Advancing the science of physical independence in older adults.
Ageing research reviews
2015
Sedentary time is associated with the metabolic syndrome in older adults with mobility limitations–The LIFE Study.
Experimental gerontology
2015
Physical activity behavior, barriers to activity, and opinions about a smartphone-based physical activity intervention among rural residents.
Telemedicine journal and e-health : the official journal of the American Telemedicine Association
2015
Mitochondrial DNA Heteroplasmy Associations With Neurosensory and Mobility Function in Elderly Adults.
The journals of gerontology. Series A, Biological sciences and medical sciences
2015
Light Intensity physical activity and sedentary behavior in relation to body mass index and grip strength in older adults: cross-sectional findings from the Lifestyle Interventions and Independence for Elders (LIFE) study.
PloS one
2015
Kaatsu training to enhance physical function of older adults with knee osteoarthritis: Design of a randomized controlled trial.
Contemporary clinical trials
2015
Interventions to reduce sedentary behavior.
Medicine and science in sports and exercise
2015
Geriatrics Consults Associated With Improved Mortality and Disposition in Hospitalized Elders
Journal of the American Geriatrics Society
2015
Associations Between Ankle-Brachial Index and Cognitive Function: Results From the Lifestyle Interventions and Independence for Elders Trial.
Journal of the American Medical Directors Association
2015
Association of objectively measured physical activity with cardiovascular risk in mobility-limited older adults.
Journal of the American Heart Association
2015
An observational study identifying obese subgroups among older adults at increased risk of mobility disability: do perceptions of the neighborhood environment matter?
The international journal of behavioral nutrition and physical activity
2015
Age Differences in Prefrontal Surface Area and Thickness in Middle Aged to Older Adults.
Frontiers in aging neuroscience
2015
A physical activity intervention to treat the frailty syndrome in older persons-results from the LIFE-P study.
The journals of gerontology. Series A, Biological sciences and medical sciences
2015
Increased inflammation but similar physical composition and function in older-aged, HIV-1 infected subjects.
BMC immunology
2015
Cross-sectional and longitudinal risk of physical impairment in a cohort of postmenopausal women who experience physical and verbal abuse.
BMC women's health
2014
Active muscle regeneration following eccentric contraction-induced injury is similar between healthy young and older adults.
Journal of applied physiology (Bethesda, Md. : 1985)
2014
Activity-related energy expenditure in older adults: a call for more research.
Medicine and science in sports and exercise
2014
Combined reduced forced expiratory volume in 1 second (FEV1) and peripheral artery disease in sedentary elders with functional limitations.
Journal of the American Medical Directors Association
2014
Change in physical activity after a diabetes diagnosis: opportunity for intervention.
Medicine and science in sports and exercise
2014
U.S. population estimates and correlates of sexual abuse of community-dwelling older adults.
Journal of elder abuse & neglect
2014
The LIFE Cognition Study: design and baseline characteristics.
Clinical interventions in aging
2014
Sedentary behavior and mortality in older women: the Women’s Health Initiative.
American journal of preventive medicine
2014
Safety and metabolic outcomes of resveratrol supplementation in older adults: results of a twelve-week, placebo-controlled pilot study.
Experimental gerontology
2014
Respiratory impairment and dyspnea and their associations with physical inactivity and mobility in sedentary community-dwelling older persons.
Journal of the American Geriatrics Society
2014
Psychological influences predict recovery following exercise induced shoulder pain.
International journal of sports medicine
2014
Patterns of circulating inflammatory biomarkers in older persons with varying levels of physical performance: a partial least squares-discriminant analysis approach.
Frontiers in medicine
2014
Simultaneous association of total energy consumption and activity-related energy expenditure with risks of cardiovascular disease, cancer, and diabetes among postmenopausal women.
American journal of epidemiology
2014
Modifying effect of obesity on the association between sitting and incident diabetes in post-menopausal women.
Obesity (Silver Spring, Md.)
2014
Mobility Impairment and Recovery During Hospitalization in Older Adults
Journal of the American Geriatrics Society
2014
Mitochondrial DNA sequence associations with dementia and amyloid-β in elderly African Americans.
Neurobiology of aging
2014
Effect of structured physical activity on prevention of major mobility disability in older adults: the LIFE study randomized clinical trial.
JAMA
2014
Effect of dietary restriction and exercise on lower extremity tissue compartments in obese, older women: a pilot study.
The journals of gerontology. Series A, Biological sciences and medical sciences
2014
Diving below the surface of progressive disability: considering compensatory strategies as evidence of sub-clinical disability.
The journals of gerontology. Series B, Psychological sciences and social sciences
2014
Obesity and late-age survival without major disease or disability in older women.
JAMA internal medicine
2013
Metabolic Rate of Walking in Fatigued Vs. Non-Fatigued Older Adults
Gerontologist
2013
Mitochondrial Function and Fatigability in Older Adults Who Report Severe Fatigue
Gerontologist
2013
Mobility decline in old age: a time to intervene.
Exercise and sport sciences reviews
2013
Neuromuscular determinants of maximum walking speed in well-functioning older adults.
Experimental gerontology
2013
Prestroke factors associated with poststroke mortality and recovery in older women in the Women’s Health Initiative.
Journal of the American Geriatrics Society
2013
Snoring, daytime sleepiness, and incident cardiovascular disease in the health, aging, and body composition study.
Sleep
2013
Skeletal muscle mitochondrial energetics are associated with maximal aerobic capacity and walking speed in older adults.
The journals of gerontology. Series A, Biological sciences and medical sciences
2013
WHAT WE HAVE LEARNED FROM EXERCISE AND LIFESTYLE TRIALS TO ALLEVIATE MOBILITY IMPAIRMENT IN OLDER ADULTS.
The Journal of frailty & aging
2013
Lumbar muscle activity during common lifts: a preliminary study using magnetic resonance imaging.
Journal of applied biomechanics
2013
Sedentary Behavior and Mortality in Older Women
The FASEB's Journal
2013
Longitudinal change in energy expenditure and effects on energy requirements of the elderly.
Nutrition journal
2013
Promoting physical activity for elders with compromised function: the lifestyle interventions and independence for elders (LIFE) study physical activity intervention.
Clinical interventions in aging
2013
Functional language networks in sedentary and physically active older adults.
Journal of the International Neuropsychological Society : JINS
2013
Effects of aerobic fitness on aging-related changes of interhemispheric inhibition and motor performance.
Frontiers in aging neuroscience
2013
Direct effects of leisure-time physical activity on walking speed.
The journal of nutrition, health & aging
2013
Designing pharmaceutical trials for sarcopenia in frail older adults: EU/US Task Force recommendations.
The journal of nutrition, health & aging
2013
Comparison of Traditional and Task-Specific Exercise On Gait in the Pre-Clinically Disabled
Gerontologist
2013
Comparison of Traditional and Task-Specific Exercise On Gait in the Pre-Clinically Disabled
Gerontologist
2013
Aging and muscle: a neuron’s perspective.
Current opinion in clinical nutrition and metabolic care
2013
Comments on point:counterpoint: skeletal muscle mechanical efficiency does/does not increase with age.
Journal of applied physiology (Bethesda, Md. : 1985)
2013
Comment: Consider Mechanical Efficiency and Comorbidity
Journal of Applied Physiology
2013
Chronic Resveratrol Supplementation and Brain Oxygenation: a Pilot Study
Gerontologist
2013
Aging, Aerobic Activity and Interhemispheric Communication
Journal of Cognitive Neuroscience
2013
Life-Cognition: Design and Baseline Data
Gerontologist
2012
Mitochondrial DNA sequence variation is associated with free-living activity energy expenditure in the elderly.
Biochimica et biophysica acta
2012
On Muscle Atrophy, Aging, and Disease
Journal of Applied Physiology
2012
Pain-related fear and catastrophizing predict pain intensity and disability independently using an induced muscle injury model.
The journal of pain : official journal of the American Pain Society
2012
Performance and Perceived Fatigability in Older Adults Who Self-Report Severe Fatigue
Gerontologist
2012
What is dynapenia?
Nutrition (Burbank, Los Angeles County, Calif.)
2012
Skeletal muscle apoptotic signaling predicts thigh muscle volume and gait speed in community-dwelling older persons: an exploratory study.
PloS one
2012
The impact of aging on mitochondrial function and biogenesis pathways in skeletal muscle of sedentary high- and low-functioning elderly individuals.
Aging cell
2012
Usefulness of preclinical models for assessing the efficacy of late-life interventions for sarcopenia.
The journals of gerontology. Series A, Biological sciences and medical sciences
2012
Growth hormone responses to acute resistance exercise with vascular restriction in young and old men.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society
2012
Relation of pulse pressure to long-distance gait speed in community-dwelling older adults: findings from the LIFE-P study.
PloS one
2012
Factors Associated With Survival After Stroke Among Elderly Women in the Whi.
Journal of the American Geriatrics Society
2012
Design and Rationale for a Long-Term Study of Physical Activity in Older Adults
Gerontologist
2012
Dynapenia and aging: an update.
The journals of gerontology. Series A, Biological sciences and medical sciences
2012
Accuracy of Perceived Exertion in Older Adults Performing Common Daily Tasks
Medicine and Science in Sports and Exercise
2012
Evaluating Moderate Intensity Walking With a Hip-Worn Accelerometer in Elders
Medicine and Science in Sports and Exercise
2012
Aging, aerobic activity and interhemispheric communication.
Brain sciences
2012
Angiotensin-converting enzyme inhibitor use by older adults is associated with greater functional responses to exercise.
Journal of the American Geriatrics Society
2012
Blood flow restriction enhances post-resistance exercise angiogenic gene expression.
Medicine and science in sports and exercise
2012
Age-related differences in lower extremity tissue compartments and associations with physical function in older adults.
Experimental gerontology
2012
Cognition Results From the Resveratrol for Improved Performance in Elders (Ripe) Trial
Gerontologist
2012
Cognitive and Structural Brain Correlates of Physical Activity and Fitness in Healthy Aging
Gerontologist
2012
Commentaries on Viewpoint: Muscle atrophy is not always sarcopenia.
Journal of applied physiology (Bethesda, Md. : 1985)
2012
Blood Flow Restriction Increases Angiogenic Gene Expression in Skeletal Muscle Following Acute Resistance Exercise
Medicine and Science in Sports and Exercise
2011
Validation of an armband to measure daily energy expenditure in older adults.
The journals of gerontology. Series A, Biological sciences and medical sciences
2011
The impact of behavioral intervention on obesity mediated declines in mobility function: implications for longevity.
Journal of aging research
2011
Relative safety of 4 weeks of blood flow-restricted resistance exercise in young, healthy adults.
Scandinavian journal of medicine & science in sports
2011
Physical activity and neural correlates of aging: a combined TMS/fMRI study.
Behavioural brain research
2011
Mitochondrial DNA variation in human metabolic rate and energy expenditure.
Mitochondrion
2011
Myogenic and proteolytic mRNA expression following blood flow restricted exercise.
Acta physiologica (Oxford, England)
2011
Metabolic cost of daily activities and effect of mobility impairment in older adults.
Journal of the American Geriatrics Society
2011
Development of physical disability in older adults.
Current aging science
2011
Effects of a weight loss plus exercise program on physical function in overweight, older women: a randomized controlled trial.
Clinical interventions in aging
2011
Commentaries on Viewpoint: Expending our physical activity (measurement) budget wisely.
Journal of applied physiology (Bethesda, Md. : 1985)
2011
Commentaries on Viewpoint: Expending our physical activity (measurement) budget wisely
Journal of Applied Physiology
2011
An exploratory analysis of the effects of a weight loss plus exercise program on cellular quality control mechanisms in older overweight women.
Rejuvenation research
2011
Activity energy expenditure and incident cognitive impairment in older adults.
Archives of internal medicine
2011
European ancestry and resting metabolic rate in older African Americans.
European journal of clinical nutrition
2010
The Effect of Functional Circuit Training On Balance and Strength in Physically Frail Older Adults
Medicine and Science in Sports and Exercise
2010
Sedentary individuals as “controls” in human studies: the correct approach?
Proceedings of the National Academy of Sciences of the United States of America
2010
Relationship between physical functioning and physical activity in the lifestyle interventions and independence for elders pilot.
Journal of the American Geriatrics Society
2010
Models of accelerated sarcopenia: critical pieces for solving the puzzle of age-related muscle atrophy.
Ageing research reviews
2010
Mitochondrial Dna Variation in Human Metabolic Rate, Energy Expenditure and Mortality: the Health, Aging and Body Composition Study
Genetic Epidemiology
2010
Functional consequences of sarcopenia and dynapenia in the elderly.
Current opinion in clinical nutrition and metabolic care
2010
The effect of functional circuit training on physical frailty in frail older adults: a randomized controlled trial.
Journal of aging and physical activity
2010
European Ancestry and Resting Metabolic Rate in Older Persons
Gerontologist
2010
Energy expenditure and aging.
Ageing research reviews
2010
Effects of exercise on mobility in obese and nonobese older adults.
Obesity (Silver Spring, Md.)
2010
Effects of age and sedentary lifestyle on skeletal muscle NF-kappaB signaling in men.
The journals of gerontology. Series A, Biological sciences and medical sciences
2010
Acute Systemic Growth Responses To Low Intensity Blood Flow Restricted Resistance Exercise in Old Men
Medicine and Science in Sports and Exercise
2010
Fibrinogen, D-Dimer and Tpa Antigen Concentrations Following Acute and Chronic Blood Flow Restricted Resistance Exercise
Medicine and Science in Sports and Exercise
2009
Sarcopenia: clinical evaluation, biological markers and other evaluation tools.
Journal of Nutrition Health & Aging
2009
Sarcopenia: clinical evaluation, biological markers and other evaluation tools.
The journal of nutrition, health & aging
2009
Sarcopenia: Clinical Evaluation, Biological Markers and Other Evaluation Tools
Journal of Nutrition Health & Aging
2009
Restoration of voluntary muscle strength after 3 weeks of cast immobilization is suppressed in women compared with men.
Archives of physical medicine and rehabilitation
2009
Physical activity and maintaining physical function in older adults.
British journal of sports medicine
2009
Organ-o-penia.
Journal of applied physiology (Bethesda, Md. : 1985)
2009
Longitudinal study of muscle strength, quality, and adipose tissue infiltration.
The American journal of clinical nutrition
2009
Delayed-onset muscle soreness induced by low-load blood flow-restricted exercise.
European journal of applied physiology
2009
Blood flow restricted exercise and skeletal muscle health.
Exercise and sport sciences reviews
2009
Activity energy expenditure and mobility limitation in older adults: differential associations by sex.
American journal of epidemiology
2009
Activity energy expenditure and change in body composition in late life.
The American journal of clinical nutrition
2009
Effects of Lifestyle Modification On Muscle Strength and Quality in Obese Older Adults
Gerontologist
2008
Sarcopenia =/= dynapenia.
The journals of gerontology. Series A, Biological sciences and medical sciences
2008
Physical function and self-rated health status as predictors of mortality: results from longitudinal analysis in the ilSIRENTE study.
BMC geriatrics
2008
Recovering From Mobility Limitation: a Common Practice Among Older Adults
Journal of the American Geriatrics Society
2008
Modulation of age-induced apoptotic signaling and cellular remodeling by exercise and calorie restriction in skeletal muscle.
Free radical biology & medicine
2008
Association of the ACTN3 genotype and physical functioning with age in older adults.
The journals of gerontology. Series A, Biological sciences and medical sciences
2008
Energy Metabolism and the Change in Body Composition During Late Life
Gerontologist
2008
Activity Energy Expenditure and the Change in Body Composition During Late Life
Medicine and Science in Sports and Exercise
2008
Energy Metabolism: Associations With Age, Fatigue and Activity
Gerontologist
2007
Effect of prolonged unweighting of human skeletal muscle on neuromotor force control.
European journal of applied physiology
2007
Efficacy of resistance and task-specific exercise in older adults who modify tasks of everyday life.
The journals of gerontology. Series A, Biological sciences and medical sciences
2007
Fatigue-induced changes in phasic muscle activation patterns during dynamic trunk extension exercise.
American journal of physical medicine & rehabilitation
2007
Knee extension strength cutpoints for maintaining mobility.
Journal of the American Geriatrics Society
2007
Reduced physical activity increases intermuscular adipose tissue in healthy young adults.
The American journal of clinical nutrition
2006
Adaptations in human neuromuscular function following prolonged unweighting: II. Neurological properties and motor imagery efficacy.
Journal of applied physiology (Bethesda, Md. : 1985)
2006
Daily activity energy expenditure and mortality among older adults.
JAMA
2006
Evaluating task modification as an objective measure of functional limitation: repeatability and comparability.
The journals of gerontology. Series A, Biological sciences and medical sciences
2006
Midlife physical activity and mobility in older age: The InCHIANTI study.
American journal of preventive medicine
2005
Sex differences in muscle fatigability and activation patterns of the human quadriceps femoris.
European journal of applied physiology
2005
Resistance and functional training reduces knee extensor position fluctuations in functionally limited older adults.
European journal of applied physiology
2005
Knee extensor isometric unsteadiness does not predict functional limitation in older adults.
American journal of physical medicine & rehabilitation
2005
Misconceptions about strength exercise among older adults.
Journal of aging and physical activity
2004
Leg muscle activity during walking with assistive devices at varying levels of weight bearing.
Archives of physical medicine and rehabilitation
2003
Derecruitment of the lumbar musculature with fatiguing trunk extension exercise.
Spine
2003
Gender differences in skeletal muscle fatigability are related to contraction type and EMG spectral compression.
Journal of applied physiology (Bethesda, Md. : 1985)
2002
Electromyographic activity of the lumbar and hip extensors during dynamic trunk extension exercise.
Archives of physical medicine and rehabilitation
2002
Electromyographic activity of the trunk extensor muscles: effect of varying hip position and lumbar posture during Roman chair exercise.
Archives of physical medicine and rehabilitation
2002
Functionally relevant thresholds of quadriceps femoris strength.
The journals of gerontology. Series A, Biological sciences and medical sciences
Effects of Fermented Papaya Preparation (FPP) on Safety Outcomes in Older Adults – A Short Report of a Placebo-Controlled Clinical Trial.
The Journal of frailty & aging
Measuring balance, lower extremity strength and gait in the elderly: construct validation of an instrument.
Archives of gerontology and geriatrics
Obesity and use of compensatory strategies to perform common daily activities in pre-clinically disabled older adults.
Archives of gerontology and geriatrics
Role of self-efficacy (SE) and anxiety among pre-clinically disabled older adults when using compensatory strategies to complete daily tasks.
Archives of gerontology and geriatrics
The relationship between interleukin-6 levels and physical performance in mobility-limited older adults with chronic low-grade inflammation: The ENRGISE Pilot study.
Archives of gerontology and geriatrics

Grants

Jun 2020 ACTIVE
Coordinating Center of the Claude D. Pepper Older Americans Independence Centers
WAKE FOREST UNIV · Principal Investigator
May 2020 ACTIVE
Translational Research Training on Aging and Mobility (TRAM)
NATL INST OF HLTH NIA · Principal Investigator
Feb 2020 ACTIVE
Investigating Movement-evoked Pain in osteoArthritic Conditions (IMPACT): An Observational Study to Inform Culturally-Tailored Intervention Development
NATL INST OF HLTH NIAMS ·
Mar 2019 ACTIVE
Wearable Technology Infrastructure to Enhance Capacity for Real-Time, Online Assessment and Mobility (ROAMM) of Intervening Health Events in Older Adults
NATL INST OF HLTH NIA · Principal Investigator
Sep 2018 ACTIVE
Multimodal imaging of brain activity to investigate walking and mobility decline in older adults
NATL INST OF HLTH NIA · Principal Investigator
Aug 2018 ACTIVE
INTERmittent pneumatic ComprEssion for Disablility rEversal in PAD: the INTERCEDE Trial
NORTHWESTERN UNIV ·
Sep 2017 ACTIVE
The University of Florida Jacksonville Aging Studies Center (JAX-ASCENT)
NATL INST OF HLTH NIA ·
Sep 2017 – May 2020
The acute development and persistence of frailty, comorbidity and disability in critically ill elderly patients after severe traumatic injury: induced frailty
NATL INST OF HLTH NIA ·
Apr 2017 ACTIVE
University of Florida Claude D. Pepper Older Americans Independence Center (OAIC)
NATL INST OF HLTH NIA ·
Dec 2016 ACTIVE
MoTrPAC Consortium Coordinating Center
NATL INST OF HLTH NIAMS ·
Apr 2016 – Mar 2017
Claude D Pepper Older Americans Independence Center
NATL INST OF HLTH NIA · Project Manager
Jan 2016 ACTIVE
ufhcc-ioa cancer-aging collaborative team grants
UF HEALTH SHANDS HOSPITAL · Project Manager
Sep 2015 – Jun 2018
Muscle mass and strength cut-points associated with mobility limitation in older adults
BRIGHAM AND WOMENS HOSPITAL · Principal Investigator
Sep 2015 – Mar 2018
PEAKS: Validation of mobile technologies for clinical assessment, monitoring, and intervention
EVERYFIT INC · Principal Investigator
Sep 2015 ACTIVE
The ENRGISE Study
NATL INST OF HLTH NIA · Project Manager
Apr 2015 – Jan 2019
Low intensity exercise intervention in peripheral artery disease
NORTHWESTERN UNIV ·
Apr 2015 – Mar 2017
A pilot study to evaluate the role of brain integrity on
UF FOU · Principal Investigator
Sep 2014 – Apr 2017
Measuring Cognitive Fatigability in Older Adults
NATL INST OF HLTH NIA · Project Manager
Sep 2014 – Jan 2019
Neural Mechanisms of Dynapenia
OHIO UNIV · Principal Investigator
Feb 2014 – Feb 2016
Health ABC database analyses for sarcopenia research
SANOFI US SERVICES · Principal Investigator
Jan 2014 – Dec 2018
MtDNA variant modifiers of cardiopulmonary responsiveness to physical activity
NATL INST OF HLTH NHLBI · Principal Investigator
Sep 2013 – Dec 2019
REVIVE – Resveratrol to enhance vitality and vigor in elders
NATL CTR FOR COMPLEM AND INTEGRATIVE HLT ·
Jul 2013 – Mar 2019
Metabolic Costs of Daily Activities in Older Adults
NATL INST OF HLTH NIA · Principal Investigator
Sep 2011 – Nov 2018
The LIFE Study
NATL INST OF HLTH NIA · Project Manager
Jul 2006 ACTIVE
21st Century Research & Economic Development Investment Program (REDIP)
STATE UNIV SYS OF FL BOARD OF GOVERNORS · Project Manager

Education

Post-Doc in Epidemiology
2006 · National Institute on Aging
PhD in Geriatric Exercise Physiology
2004 · Syracuse University
Certificate of Advanced Study in Gerontology
2001 · Syracuse University
Masters of Science in Exercise Physiology
2000 · Syracuse University
Bachelors of Science in Biology
1997 · Ohio University

Contact Details

Phones:
Business:
(352) 273-5914
Emails:
Business:
tmanini@ufl.edu