Todd Manini, Ph.D.
Professor; Chief, Division Of EDGE
Department:
MD-AGING-CLINICAL RESEARCH
Business Phone:
(352) 273-5914
Business Email:
tmanini@ufl.edu
About Todd Manini
Dr. Manini is a Professor at UF’s College of Medicine in the Department of Aging and Geriatric Research. He is the Chief of the newly formed Division of Epidemiology and Data science in Gerontology (EDGE) and leads the Data Science and Applied Technology Core at the UF Claude D. Pepper Older American’s Independence Center. He is recognized for his work on the sarcopenia and dynapenia, frailty, activity epidemiology, and energy metabolism specifically focused in older adults. Recently, he has gained considerable recognition for his team science work on wearable mobile technology (e.g. smart watches) that will allow an unprecedented understanding of the exposome—environmental and behavioral exposures in the free-living world— and their impact on geriatric syndromes. He currently receives or has received support from the National Heart, Lung and Blood Institute, National Cancer Institute and National Institute on Aging to conduct this work. At an international level, he has fellow status at two societies: The American College of Sports Medicine and The Gerontological Society of America (GSA). He is the Chair of the American College of Sports Medicine Strategic Health Initiative on Aging and he carried this leadership to the GSA where he served as the Co-Chair of the Measurement, Statistics, and Research Design (MSRD) Interest Group. He was a steering committee member of the Sarcopenia Definition and Outcomes Consortium that provided unprecedent new knowledge for defining sarcopenia for clinical use. He was also honored with being a standing member on NIH’s Center for Scientific Review as part of the Neurological, Aging and Musculoskeletal Epidemiology (NAME) Study Section. Lastly, he is serving as an Associated Editor of the Journals of Gerontology: Medical Sciences since 2020. He is an active mentor and teacher that strives to provide opportunities for the next generation of scientists. He was awarded in 2011 with the UF College of Medicine Exemplary Teachers Award and in 2018 he was recognized as a Master Mentor. He also graduated from the inaugural class of the UF’s Clinical and Translational Science Institute’s Academy of Research Excellence which emphasizes rigor and reproducibility. He is the principal investigator of a new National Institute on Aging training program called TRAM— Translational Research on Aging and Mobility. The training program is centered on mentoring trainees on translational research to preserve mobility in late-life. In his spare time, he enjoys spending time with his wife and trying to being a great father to his son and daughter. He is a perpetual learner always keeping busy not only as a scientist, but a handyman, devoted podcast listener, avid disc golfer, ball golfer, chess and billiards player, soccer coach, and Minecraft gamer.
Publications
2021
Age Differences in Estimating Physical Activity by Wrist Accelerometry Using Machine Learning.
Sensors (Basel, Switzerland).
21(10)
[DOI] 10.3390/s21103352.
[PMID] 34065906.
2021
Differences in Health-Related Quality of Life Among Adults with a Potential Dihydropyridine Calcium Channel Blocker-Loop Diuretic Prescribing Cascade.
Drugs & aging.
38(7):625-632
[DOI] 10.1007/s40266-021-00868-0.
[PMID] 34095980.
2021
Effect of a Multifactorial Fall Injury Prevention Intervention on Patient Well-Being: The STRIDE Study.
Journal of the American Geriatrics Society.
69(1):173-179
[DOI] 10.1111/jgs.16854.
[PMID] 33037632.
2021
Effect of Low-Intensity vs High-Intensity Home-Based Walking Exercise on Walk Distance in Patients With Peripheral Artery Disease: The LITE Randomized Clinical Trial.
JAMA.
325(13):1266-1276
[DOI] 10.1001/jama.2021.2536.
[PMID] 33821898.
2021
Elevated IL-6 and CRP levels are associated with incident self-reported major mobility disability: A pooled analysis of older adults with slow gait speed.
The journals of gerontology. Series A, Biological sciences and medical sciences.
[DOI] 10.1093/gerona/glab093.
[PMID] 33822946.
2021
Evaluation of a Strength-Training Program on Clinical Outcomes in Older Adults.
JAMA.
325(11)
[DOI] 10.1001/jama.2021.0298.
[PMID] 33724318.
2021
Ratings of Perceived Exertion during Walking: Predicting Major Mobility Disability and Effect of Structured Physical Activity in Mobility-Limited Older Adults.
The journals of gerontology. Series A, Biological sciences and medical sciences.
[DOI] 10.1093/gerona/glab036.
[PMID] 33585918.
2021
Reduced Neural Excitability and Activation Contribute to Clinically Meaningful Weakness in Older Adults.
The journals of gerontology. Series A, Biological sciences and medical sciences.
76(4):692-702
[DOI] 10.1093/gerona/glaa157.
[PMID] 32588058.
2021
Study Protocol Modeling Evoked Pain in Older African Americans with Knee Osteoarthritis.
Nursing research.
[DOI] 10.1097/NNR.0000000000000520.
[PMID] 33951704.
2021
Survey-reported medication changes among older adults during the SARS-CoV-2 (COVID-19) pandemic.
Research in social & administrative pharmacy : RSAP.
17(8):1478-1482
[DOI] 10.1016/j.sapharm.2020.11.005.
[PMID] 33221267.
2021
Sustained physical activity in peripheral artery disease: Associations with disease severity, functional performance, health-related quality of life, and subsequent serious adverse events in the LITE randomized clinical trial.
Vascular medicine (London, England).
[DOI] 10.1177/1358863X21989430.
[PMID] 33829920.
2021
The Effect of Sensor Placement and Number on Physical Activity Recognition and Energy Expenditure Estimation in Older Adults: Validation Study.
JMIR mHealth and uHealth.
9(5)
[DOI] 10.2196/23681.
[PMID] 33938809.
2021
The Temporal Relationship Between Ecological Pain and Life-Space Mobility in Older Adults With Knee Osteoarthritis: A Smartwatch-Based Demonstration Study.
JMIR mHealth and uHealth.
9(1)
[DOI] 10.2196/19609.
[PMID] 33439135.
2021
Three-Year, Postintervention, Follow-up Comparison of Health Care Resource Utilization and Costs in the Lifestyle Interventions and Independence for Elders (LIFE) Study.
The journals of gerontology. Series A, Biological sciences and medical sciences.
76(2):272-276
[DOI] 10.1093/gerona/glaa088.
[PMID] 32270182.
2021
What cut-point in gait speed best discriminates community dwelling older adults with mobility complaints from those without? A pooled analysis from the Sarcopenia Definitions and Outcomes Consortium.
The journals of gerontology. Series A, Biological sciences and medical sciences.
[DOI] 10.1093/gerona/glab183.
[PMID] 34166490.
2020
A Simulated Graphical Interface for Integrating Patient-Generated Health Data From Smartwatches With Electronic Health Records: Usability Study.
JMIR human factors.
7(4)
[DOI] 10.2196/19769.
[PMID] 33124988.
2020
Altered Expression of Mitoferrin and Frataxin, Larger Labile Iron Pool and Greater Mitochondrial DNA Damage in the Skeletal Muscle of Older Adults.
Cells.
9(12)
[DOI] 10.3390/cells9122579.
[PMID] 33276460.
2020
Application of Cut-Points for Low Muscle Strength and Lean Mass in Mobility-Limited Older Adults.
Journal of the American Geriatrics Society.
68(7):1445-1453
[DOI] 10.1111/jgs.16525.
[PMID] 32633836.
2020
Application of SDOC Cut Points for Low Muscle Strength for Recovery of Walking Speed After Hip Fracture.
The journals of gerontology. Series A, Biological sciences and medical sciences.
75(7):1379-1385
[DOI] 10.1093/gerona/glaa076.
[PMID] 32242218.
2020
Application of Selected Muscle Strength and Body Mass Cut Points for the Diagnosis of Sarcopenia in Men and Women With or at Risk for HIV Infection.
The journals of gerontology. Series A, Biological sciences and medical sciences.
75(7):1338-1345
[DOI] 10.1093/gerona/glaa083.
[PMID] 32301484.
2020
Association between a Deficit Accumulation Frailty Index and Mobility Outcomes in Older Adults: Secondary Analysis of the Lifestyle Interventions and Independence for Elders (LIFE) Study.
Journal of clinical medicine.
9(11)
[DOI] 10.3390/jcm9113757.
[PMID] 33266358.
2020
Association of Fish Oil and Physical Activity on Mobility Disability in Older Adults.
Medicine and science in sports and exercise.
52(4):859-867
[DOI] 10.1249/MSS.0000000000002195.
[PMID] 31688650.
2020
Comparative Effects of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers on Response to a Physical Activity Intervention in Older Adults: Results From the Lifestyle Interventions and Independence for Elders Study.
The journals of gerontology. Series A, Biological sciences and medical sciences.
75(5):1010-1016
[DOI] 10.1093/gerona/glz120.
[PMID] 31070702.
2020
Comparison of a Multi-Component Physical Function Battery to Usual Walking Speed for Assessing Lower Extremity Function and Mobility Limitation in Older Adults.
The journal of nutrition, health & aging.
24(8):906-913
[DOI] 10.1007/s12603-020-1432-2.
[PMID] 33009544.
2020
Corrigendum: Multimodal Imaging of Brain Activity to Investigate Walking and Mobility Decline in Older Adults (Mind in Motion Study): Hypothesis, Theory, and Methods.
Frontiers in aging neuroscience.
12
[DOI] 10.3389/fnagi.2020.00063.
[PMID] 32194394.
2020
Deep CHORES: Estimating Hallmark Measures of Physical Activity Using Deep Learning.
AMIA … Annual Symposium proceedings. AMIA Symposium.
2020:803-812
[PMID] 33936455.
View on:
PubMed
2020
Establishing the Link Between Lean Mass and Grip Strength Cut Points With Mobility Disability and Other Health Outcomes: Proceedings of the Sarcopenia Definition and Outcomes Consortium Conference.
The journals of gerontology. Series A, Biological sciences and medical sciences.
75(7):1317-1323
[DOI] 10.1093/gerona/glz081.
[PMID] 30869772.
2020
Evaluation of the Potential Acetylcholinesterase Inhibitor-Induced Rhinorrhea Prescribing Cascade.
Journal of the American Geriatrics Society.
68(2):440-441
[DOI] 10.1111/jgs.16224.
[PMID] 31625144.
2020
Healthcare Utilization and Physical Functioning in Older Adults in the United States.
Journal of the American Geriatrics Society.
68(2):266-271
[DOI] 10.1111/jgs.16260.
[PMID] 31755551.
2020
Higher dose of resveratrol elevated cardiovascular disease risk biomarker levels in overweight older adults – A pilot study.
Experimental gerontology.
131
[DOI] 10.1016/j.exger.2019.110821.
[PMID] 31891746.
2020
Identification of Sarcopenia Components That Discriminate Slow Walking Speed: A Pooled Data Analysis.
Journal of the American Geriatrics Society.
68(7):1419-1428
[DOI] 10.1111/jgs.16524.
[PMID] 32633834.
2020
Impact and Lessons From the Lifestyle Interventions and Independence for Elders (LIFE) Clinical Trials of Physical Activity to Prevent Mobility Disability.
Journal of the American Geriatrics Society.
68(4):872-881
[DOI] 10.1111/jgs.16365.
[PMID] 32105353.
2020
Impact of Anticholinergic Medication Burden on Mobility and Falls in the Lifestyle Interventions for Elders (LIFE) Study.
Journal of clinical medicine.
9(9)
[DOI] 10.3390/jcm9092989.
[PMID] 32947839.
2020
Impact of Baseline Fatigue on a Physical Activity Intervention to Prevent Mobility Disability.
Journal of the American Geriatrics Society.
68(3):619-624
[DOI] 10.1111/jgs.16274.
[PMID] 31867713.
2020
Innovations in Geroscience to enhance mobility in older adults.
Experimental gerontology.
142
[DOI] 10.1016/j.exger.2020.111123.
[PMID] 33191210.
2020
Putative Cut-Points in Sarcopenia Components and Incident Adverse Health Outcomes: An SDOC Analysis.
Journal of the American Geriatrics Society.
68(7):1429-1437
[DOI] 10.1111/jgs.16517.
[PMID] 32633824.
2020
Relative contribution of muscle strength, lean mass, and lower extremity motor function in explaining between-person variance in mobility in older adults.
BMC geriatrics.
20(1)
[DOI] 10.1186/s12877-020-01656-y.
[PMID] 32723298.
2020
Sarcopenia Definition & Outcomes Consortium Defined Low Grip Strength in Two Cross-Sectional, Population-Based Cohorts.
Journal of the American Geriatrics Society.
68(7):1438-1444
[DOI] 10.1111/jgs.16419.
[PMID] 32633830.
2020
Sarcopenia Definition: The Position Statements of the Sarcopenia Definition and Outcomes Consortium.
Journal of the American Geriatrics Society.
68(7):1410-1418
[DOI] 10.1111/jgs.16372.
[PMID] 32150289.
2020
Secondary care provider attitudes towards patient generated health data from smartwatches.
NPJ digital medicine.
3
[DOI] 10.1038/s41746-020-0236-4.
[PMID] 32140569.
2020
The relationship between interleukin-6 levels and physical performance in mobility-limited older adults with chronic low-grade inflammation: The ENRGISE Pilot study.
Archives of gerontology and geriatrics.
90
[DOI] 10.1016/j.archger.2020.104131.
[PMID] 32554219.
2020
Trajectories of Short Physical Performance Battery Are Strongly Associated with Future Major Mobility Disability: Results from the LIFE Study.
Journal of clinical medicine.
9(8)
[DOI] 10.3390/jcm9082332.
[PMID] 32707877.
2020
Transcutaneous Electrical Stimulation on the Submental Area: The Relations of Biopsychological Factors with Maximum Amplitude Tolerance and Perceived Discomfort Level.
Dysphagia.
35(2):301-307
[DOI] 10.1007/s00455-019-10029-6.
[PMID] 31209638.
2019
A Case for Promoting Movement Medicine: Preventing Disability in the LIFE Randomized Controlled Trial.
The journals of gerontology. Series A, Biological sciences and medical sciences.
74(11):1821-1827
[DOI] 10.1093/gerona/glz050.
[PMID] 30778518.
2019
A comparison of accelerometry analysis methods for physical activity in older adult women and associations with health outcomes over time.
Journal of sports sciences.
37(20):2309-2317
[DOI] 10.1080/02640414.2019.1631080.
[PMID] 31195893.
2019
A smartwatch-based framework for real-time and online assessment and mobility monitoring.
Journal of biomedical informatics.
89:29-40
[DOI] 10.1016/j.jbi.2018.11.003.
[PMID] 30414474.
2019
Accuracy of Samsung Gear S Smartwatch for Activity Recognition: Validation Study.
JMIR mHealth and uHealth.
7(2)
[DOI] 10.2196/11270.
[PMID] 30724739.
2019
Advanced Age Is Associated with Iron Dyshomeostasis and Mitochondrial DNA Damage in Human Skeletal Muscle.
Cells.
8(12)
[DOI] 10.3390/cells8121525.
[PMID] 31783583.
2019
Blood Flow-restricted Exercise Does Not Induce a Cross-Transfer of Effect: A Randomized Controlled Trial.
Medicine and science in sports and exercise.
51(9):1817-1827
[DOI] 10.1249/MSS.0000000000001984.
[PMID] 30913160.
2019
Blood-Flow Restriction Resistance Exercise for Older Adults with Knee Osteoarthritis: A Pilot Randomized Clinical Trial.
Journal of clinical medicine.
8(2)
[DOI] 10.3390/jcm8020265.
[PMID] 30795545.
2019
Effect of Gastric Acid Suppressants on Response to a Physical Activity Intervention and Major Mobility Disability in Older Adults: Results from the Lifestyle Interventions for Elders (LIFE) Study.
Pharmacotherapy.
39(8):816-826
[DOI] 10.1002/phar.2299.
[PMID] 31230397.
2019
Effect of Hospitalizations on Physical Activity Patterns in Mobility-Limited Older Adults.
Journal of the American Geriatrics Society.
67(2):261-268
[DOI] 10.1111/jgs.15631.
[PMID] 30452084.
2019
Effect of Losartan and Fish Oil on Plasma IL-6 and Mobility in Older Persons. The ENRGISE Pilot Randomized Clinical Trial.
The journals of gerontology. Series A, Biological sciences and medical sciences.
74(10):1612-1619
[DOI] 10.1093/gerona/gly277.
[PMID] 30541065.
2019
Magnitude of and Characteristics Associated With the Treatment of Calcium Channel Blocker-Induced Lower-Extremity Edema With Loop Diuretics.
JAMA network open.
2(12)
[DOI] 10.1001/jamanetworkopen.2019.18425.
[PMID] 31880802.
2019
Mitochondrial DNA variants and pulmonary function in older persons.
Experimental gerontology.
115:96-103
[DOI] 10.1016/j.exger.2018.11.023.
[PMID] 30508565.
2019
Movement-evoked pain: transforming the way we understand and measure pain.
Pain.
160(4):757-761
[DOI] 10.1097/j.pain.0000000000001431.
[PMID] 30371555.
2019
Multimodal Imaging of Brain Activity to Investigate Walking and Mobility Decline in Older Adults (Mind in Motion Study): Hypothesis, Theory, and Methods.
Frontiers in aging neuroscience.
11
[DOI] 10.3389/fnagi.2019.00358.
[PMID] 31969814.
2019
Perception of Older Adults Toward Smartwatch Technology for Assessing Pain and Related Patient-Reported Outcomes: Pilot Study.
JMIR mHealth and uHealth.
7(3)
[DOI] 10.2196/10044.
[PMID] 30912756.
2019
Role of Wearable Accelerometer Devices in Delirium Studies: A Systematic Review.
Critical care explorations.
1(9)
[DOI] 10.1097/CCE.0000000000000027.
[PMID] 32166280.
2019
The Effects of Electrical Stimulation Pulse Duration on Lingual Palatal Pressure Measures During Swallowing in Healthy Older Adults.
Dysphagia.
34(4):529-539
[DOI] 10.1007/s00455-019-09991-y.
[PMID] 30820657.
2019
The Effects of Time Restricted Feeding on Overweight, Older Adults: A Pilot Study.
Nutrients.
11(7)
[DOI] 10.3390/nu11071500.
[PMID] 31262054.
2019
The Enabling Reduction of Low-Grade Inflammation in Seniors (ENRGISE) Pilot Study: Screening Methods and Recruitment Results.
The journals of gerontology. Series A, Biological sciences and medical sciences.
74(8):1296-1302
[DOI] 10.1093/gerona/gly204.
[PMID] 30202946.
2019
Translating the Lifestyle Interventions and Independence for Elders Clinical Trial to Older Adults in a Real-World Community-Based Setting.
The journals of gerontology. Series A, Biological sciences and medical sciences.
74(6):924-928
[DOI] 10.1093/gerona/gly152.
[PMID] 30010808.
2019
Voluntary vs Electrically Stimulated Activation in Age-Related Muscle Weakness.
JAMA network open.
2(9)
[DOI] 10.1001/jamanetworkopen.2019.12052.
[PMID] 31553466.
2019
Wearable Technology To Reduce Sedentary Behavior And CVD Risk In Older Adults: A Pilot Randomized Clinical Trial.
Clinical interventions in aging.
14:1817-1828
[DOI] 10.2147/CIA.S222655.
[PMID] 31695350.
2018
A Comparison of Self-report Indices of Major Mobility Disability to Failure on the 400-m Walk Test: The LIFE Study.
The journals of gerontology. Series A, Biological sciences and medical sciences.
73(4):513-518
[DOI] 10.1093/gerona/glx153.
[PMID] 28958023.
2018
Activity and Circadian Rhythm of Sepsis Patients in the Intensive Care Unit.
… IEEE-EMBS International Conference on Biomedical and Health Informatics. IEEE-EMBS International Conference on Biomedical and Health Informatics.
2018:17-20
[DOI] 10.1109/BHI.2018.8333359.
[PMID] 30411088.
2018
Associations between ACE-Inhibitors, Angiotensin Receptor Blockers, and Lean Body Mass in Community Dwelling Older Women.
Journal of aging research.
2018
[DOI] 10.1155/2018/8491092.
[PMID] 29670769.
2018
Comment on: “Pitfalls in the measurement of muscle mass: a need for a reference standard” by Buckinx et al.
Journal of cachexia, sarcopenia and muscle.
9(7):1269-1271
[DOI] 10.1002/jcsm.12372.
[PMID] 30680964.
2018
Community-Based Activity and Sedentary Patterns Are Associated With Cognitive Performance in Mobility-Limited Older Adults.
Frontiers in aging neuroscience.
10
[DOI] 10.3389/fnagi.2018.00341.
[PMID] 30498440.
2018
Diet and Activity Assessments and Interventions Using Technology in Older Adults.
American journal of preventive medicine.
55(4):e105-e115
[DOI] 10.1016/j.amepre.2018.06.005.
[PMID] 30241621.
2018
Dopamine-Related Genotypes and Physical Activity Change During an Intervention: The Lifestyle Interventions and Independence for Elders Study.
Journal of the American Geriatrics Society.
66(6):1172-1179
[DOI] 10.1111/jgs.15369.
[PMID] 29637543.
2018
Effect of 24-month physical activity on cognitive frailty and the role of inflammation: the LIFE randomized clinical trial.
BMC medicine.
16(1)
[DOI] 10.1186/s12916-018-1174-8.
[PMID] 30352583.
2018
Effect of Physical Activity on Frailty: Secondary Analysis of a Randomized Controlled Trial.
Annals of internal medicine.
168(5):309-316
[DOI] 10.7326/M16-2011.
[PMID] 29310138.
2018
Effects of 90 Days of Resveratrol Supplementation on Cognitive Function in Elders: A Pilot Study.
Journal of alternative and complementary medicine (New York, N.Y.).
24(7):725-732
[DOI] 10.1089/acm.2017.0398.
[PMID] 29583015.
2018
Effects of Fermented Papaya Preparation (FPP) on Safety Outcomes in Older Adults – A Short Report of a Placebo-Controlled Clinical Trial.
The Journal of frailty & aging.
7(2):142-146
[DOI] 10.14283/jfa.2018.6.
[PMID] 29741201.
2018
Evaluating Accelerometry Thresholds for Detecting Changes in Levels of Moderate Physical Activity and Resulting Major Mobility Disability.
The journals of gerontology. Series A, Biological sciences and medical sciences.
73(5):660-667
[DOI] 10.1093/gerona/glx132.
[PMID] 28977340.
2018
Evidence-based nutritional and pharmacological interventions targeting chronic low-grade inflammation in middle-age and older adults: A systematic review and meta-analysis.
Ageing research reviews.
46:42-59
[DOI] 10.1016/j.arr.2018.05.004.
[PMID] 29803716.
2018
Gait Speed and Mobility Disability: Revisiting Meaningful Levels in Diverse Clinical Populations.
Journal of the American Geriatrics Society.
66(5):954-961
[DOI] 10.1111/jgs.15331.
[PMID] 29608795.
2018
Maintenance of Physical Function 1 Year After Exercise Intervention in At-Risk Older Adults: Follow-up From the LIFE Study.
The journals of gerontology. Series A, Biological sciences and medical sciences.
73(5):688-694
[DOI] 10.1093/gerona/glx231.
[PMID] 29490012.
2018
Meta-analysis identifies mitochondrial DNA sequence variants associated with walking speed.
GeroScience.
40(5-6):497-511
[DOI] 10.1007/s11357-018-0043-x.
[PMID] 30338417.
2018
Mitochondrial DNA m.13514G>A heteroplasmy is associated with depressive symptoms in the elderly.
International journal of geriatric psychiatry.
33(10):1319-1326
[DOI] 10.1002/gps.4928.
[PMID] 29984425.
2018
Mitochondrial DNA m.3243A > G heteroplasmy affects multiple aging phenotypes and risk of mortality.
Scientific reports.
8(1)
[DOI] 10.1038/s41598-018-30255-6.
[PMID] 30089816.
2018
Mitochondrial DNA Sequence Variants Associated With Blood Pressure Among 2 Cohorts of Older Adults.
Journal of the American Heart Association.
7(18)
[DOI] 10.1161/JAHA.118.010009.
[PMID] 30371200.
2018
Self-Reported Physical Function As a Predictor of Hospitalization in the Lifestyle Interventions and Independence for Elders Study.
Journal of the American Geriatrics Society.
66(10):1927-1933
[DOI] 10.1111/jgs.15468.
[PMID] 30281796.
2018
Social Participation Modifies the Effect of a Structured Physical Activity Program on Major Mobility Disability Among Older Adults: Results From the LIFE Study.
The journals of gerontology. Series B, Psychological sciences and social sciences.
73(8):1501-1513
[DOI] 10.1093/geronb/gbx051.
[PMID] 28482106.
2018
The Influence of Physical Activity and Sedentary Behavior on Living to Age 85 Years Without Disease and Disability in Older Women.
The journals of gerontology. Series A, Biological sciences and medical sciences.
73(11):1525-1531
[DOI] 10.1093/gerona/glx222.
[PMID] 29165626.
2018
Transition Icons for Time-Series Visualization and Exploratory Analysis.
IEEE journal of biomedical and health informatics.
22(2):623-630
[DOI] 10.1109/JBHI.2017.2704608.
[PMID] 28534797.
2018
Wrist accelerometer shape feature derivation methods for assessing activities of daily living.
BMC medical informatics and decision making.
18(Suppl 4)
[DOI] 10.1186/s12911-018-0671-1.
[PMID] 30537957.
2017
A New Adaptive Home-based Exercise Technology among Older Adults Living in Nursing Home: A Pilot Study on Feasibility, Acceptability and Physical Performance.
The journal of nutrition, health & aging.
21(7):819-824
[DOI] 10.1007/s12603-016-0820-0.
[PMID] 28717812.
2017
A new approach to disentangle genetic and epigenetic components on disease comorbidities: studying correlation between genotypic and phenotypic disease networks.
Procedia computer science.
110:453-458
[DOI] 10.1016/j.procs.2017.06.119.
[PMID] 32318124.
2017
Association between age-related reductions in testosterone and risk of prostate cancer-An analysis of patients’ data with prostatic diseases.
International journal of cancer.
141(9):1783-1793
[DOI] 10.1002/ijc.30882.
[PMID] 28699177.
2017
Association Between Structured Physical Activity and Sedentary Time in Older Adults.
JAMA.
318(3):297-299
[DOI] 10.1001/jama.2017.7203.
[PMID] 28719683.
2017
Association of Accelerometer-Measured Physical Activity With Leukocyte Telomere Length Among Older Women.
The journals of gerontology. Series A, Biological sciences and medical sciences.
72(11):1532-1537
[DOI] 10.1093/gerona/glx037.
[PMID] 28329327.
2017
Association of Accelerometry-Measured Physical Activity and Cardiovascular Events in Mobility-Limited Older Adults: The LIFE (Lifestyle Interventions and Independence for Elders) Study.
Journal of the American Heart Association.
6(12)
[DOI] 10.1161/JAHA.117.007215.
[PMID] 29197830.
2017
Associations of Accelerometer-Measured and Self-Reported Sedentary Time With Leukocyte Telomere Length in Older Women.
American journal of epidemiology.
185(3):172-184
[DOI] 10.1093/aje/kww196.
[PMID] 28100466.
2017
Blood flow restricted resistance training in older adults at risk of mobility limitations.
Experimental gerontology.
99:138-145
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[DOI] 10.1016/j.archger.2012.06.007.
[PMID] 22770713.
2012
Skeletal muscle apoptotic signaling predicts thigh muscle volume and gait speed in community-dwelling older persons: an exploratory study.
PloS one.
7(2)
[DOI] 10.1371/journal.pone.0032829.
[PMID] 22389725.
2012
The impact of aging on mitochondrial function and biogenesis pathways in skeletal muscle of sedentary high- and low-functioning elderly individuals.
Aging cell.
11(5):801-9
[DOI] 10.1111/j.1474-9726.2012.00844.x.
[PMID] 22681576.
2012
Usefulness of preclinical models for assessing the efficacy of late-life interventions for sarcopenia.
The journals of gerontology. Series A, Biological sciences and medical sciences.
67(1):17-27
[DOI] 10.1093/gerona/glr042.
[PMID] 21636833.
2012
What is dynapenia?
Nutrition (Burbank, Los Angeles County, Calif.).
28(5):495-503
[DOI] 10.1016/j.nut.2011.12.002.
[PMID] 22469110.
2011
Activity energy expenditure and incident cognitive impairment in older adults.
Archives of internal medicine.
171(14):1251-7
[DOI] 10.1001/archinternmed.2011.277.
[PMID] 21771893.
2011
An exploratory analysis of the effects of a weight loss plus exercise program on cellular quality control mechanisms in older overweight women.
Rejuvenation research.
14(3):315-24
[DOI] 10.1089/rej.2010.1132.
[PMID] 21631380.
2011
Commentaries on Viewpoint: Expending our physical activity (measurement) budget wisely
Journal of Applied Physiology.
[DOI] 10.1152/japplphysiol.00650.2011.
[PMID] 21828253.
2011
Commentaries on Viewpoint: Expending our physical activity (measurement) budget wisely.
Journal of applied physiology (Bethesda, Md. : 1985).
111(2)
[DOI] 10.1152/japplphysiol.00650.2011.
[PMID] 21828253.
2011
Development of physical disability in older adults.
Current aging science.
4(3):184-91
[PMID] 21529321.
View on:
PubMed
2011
Effects of a weight loss plus exercise program on physical function in overweight, older women: a randomized controlled trial.
Clinical interventions in aging.
6:141-9
[DOI] 10.2147/CIA.S17001.
[PMID] 21753869.
2011
European ancestry and resting metabolic rate in older African Americans.
European journal of clinical nutrition.
65(6):663-7
[DOI] 10.1038/ejcn.2011.22.
[PMID] 21468093.
2011
Metabolic cost of daily activities and effect of mobility impairment in older adults.
Journal of the American Geriatrics Society.
59(11):2118-23
[DOI] 10.1111/j.1532-5415.2011.03655.x.
[PMID] 22091979.
2011
Mitochondrial DNA variation in human metabolic rate and energy expenditure.
Mitochondrion.
11(6):855-61
[DOI] 10.1016/j.mito.2011.04.005.
[PMID] 21586348.
2011
Myogenic and proteolytic mRNA expression following blood flow restricted exercise.
Acta physiologica (Oxford, England).
201(2):255-63
[DOI] 10.1111/j.1748-1716.2010.02172.x.
[PMID] 20653608.
2011
Physical activity and neural correlates of aging: a combined TMS/fMRI study.
Behavioural brain research.
222(1):158-68
[DOI] 10.1016/j.bbr.2011.03.042.
[PMID] 21440574.
2011
Relative safety of 4 weeks of blood flow-restricted resistance exercise in young, healthy adults.
Scandinavian journal of medicine & science in sports.
21(5):653-62
[DOI] 10.1111/j.1600-0838.2010.01100.x.
[PMID] 21917016.
2011
The impact of behavioral intervention on obesity mediated declines in mobility function: implications for longevity.
Journal of aging research.
2011
[DOI] 10.4061/2011/392510.
[PMID] 22013527.
2011
Validation of an armband to measure daily energy expenditure in older adults.
The journals of gerontology. Series A, Biological sciences and medical sciences.
66(10):1108-13
[DOI] 10.1093/gerona/glr101.
[PMID] 21734231.
2010
Acute Systemic Growth Responses To Low Intensity Blood Flow Restricted Resistance Exercise in Old Men
Medicine and Science in Sports and Exercise.
42
2010
Effects of age and sedentary lifestyle on skeletal muscle NF-kappaB signaling in men.
The journals of gerontology. Series A, Biological sciences and medical sciences.
65(5):532-7
[DOI] 10.1093/gerona/glp196.
[PMID] 20045871.
2010
Effects of exercise on mobility in obese and nonobese older adults.
Obesity (Silver Spring, Md.).
18(6):1168-75
[DOI] 10.1038/oby.2009.317.
[PMID] 19834467.
2010
Energy expenditure and aging.
Ageing research reviews.
9(1):1-11
[DOI] 10.1016/j.arr.2009.08.002.
[PMID] 19698803.
2010
European Ancestry and Resting Metabolic Rate in Older Persons
Gerontologist.
50
2010
Fibrinogen, D-Dimer and Tpa Antigen Concentrations Following Acute and Chronic Blood Flow Restricted Resistance Exercise
Medicine and Science in Sports and Exercise.
42
2010
Functional consequences of sarcopenia and dynapenia in the elderly.
Current opinion in clinical nutrition and metabolic care.
13(3):271-6
[DOI] 10.1097/MCO.0b013e328337819e.
[PMID] 20154609.
2010
Measuring balance, lower extremity strength and gait in the elderly: construct validation of an instrument.
Archives of gerontology and geriatrics.
51(2):199-204
[DOI] 10.1016/j.archger.2009.10.008.
[PMID] 19914723.
2010
Mitochondrial Dna Variation in Human Metabolic Rate, Energy Expenditure and Mortality: the Health, Aging and Body Composition Study
Genetic Epidemiology.
34
2010
Models of accelerated sarcopenia: critical pieces for solving the puzzle of age-related muscle atrophy.
Ageing research reviews.
9(4):369-83
[DOI] 10.1016/j.arr.2010.04.004.
[PMID] 20438881.
2010
Relationship between physical functioning and physical activity in the lifestyle interventions and independence for elders pilot.
Journal of the American Geriatrics Society.
58(10):1918-24
[DOI] 10.1111/j.1532-5415.2010.03008.x.
[PMID] 20738437.
2010
Sedentary individuals as “controls” in human studies: the correct approach?
Proceedings of the National Academy of Sciences of the United States of America.
107(34)
[DOI] 10.1073/pnas.1008118107.
[PMID] 20660311.
2010
The Effect of Functional Circuit Training On Balance and Strength in Physically Frail Older Adults
Medicine and Science in Sports and Exercise.
42
2010
The effect of functional circuit training on physical frailty in frail older adults: a randomized controlled trial.
Journal of aging and physical activity.
18(4):401-24
[PMID] 20956842.
View on:
PubMed
2009
Activity energy expenditure and change in body composition in late life.
The American journal of clinical nutrition.
90(5):1336-42
[DOI] 10.3945/ajcn.2009.27659.
[PMID] 19740971.
2009
Activity energy expenditure and mobility limitation in older adults: differential associations by sex.
American journal of epidemiology.
169(12):1507-16
[DOI] 10.1093/aje/kwp069.
[PMID] 19383938.
2009
Blood flow restricted exercise and skeletal muscle health.
Exercise and sport sciences reviews.
37(2):78-85
[DOI] 10.1097/JES.0b013e31819c2e5c.
[PMID] 19305199.
2009
Delayed-onset muscle soreness induced by low-load blood flow-restricted exercise.
European journal of applied physiology.
107(6):687-95
[DOI] 10.1007/s00421-009-1175-6.
[PMID] 19727801.
2009
Effects of Lifestyle Modification On Muscle Strength and Quality in Obese Older Adults
Gerontologist.
49
2009
Longitudinal study of muscle strength, quality, and adipose tissue infiltration.
The American journal of clinical nutrition.
90(6):1579-85
[DOI] 10.3945/ajcn.2009.28047.
[PMID] 19864405.
2009
Organ-o-penia.
Journal of applied physiology (Bethesda, Md. : 1985).
106(6):1759-60
[DOI] 10.1152/japplphysiol.00315.2009.
[PMID] 19359616.
2009
Physical activity and maintaining physical function in older adults.
British journal of sports medicine.
43(1):28-31
[DOI] 10.1136/bjsm.2008.053736.
[PMID] 18927164.
2009
Restoration of voluntary muscle strength after 3 weeks of cast immobilization is suppressed in women compared with men.
Archives of physical medicine and rehabilitation.
90(1):178-80
[DOI] 10.1016/j.apmr.2008.06.032.
[PMID] 19154845.
2009
Sarcopenia: Clinical Evaluation, Biological Markers and Other Evaluation Tools
Journal of Nutrition Health & Aging.
13(24):724-728
[DOI] 10.1007/s12603-009-0204-9.
[PMID] 17189400.
2009
Sarcopenia: clinical evaluation, biological markers and other evaluation tools.
The journal of nutrition, health & aging.
13(8):724-8
[PMID] 19657557.
View on:
PubMed
2009
Sarcopenia: clinical evaluation, biological markers and other evaluation tools.
Journal of Nutrition Health & Aging.
13(8)
[DOI] 10.1007/s12603-009-0204-9.
[PMID] 19657557.
2008
Activity Energy Expenditure and the Change in Body Composition During Late Life
Medicine and Science in Sports and Exercise.
40(5)
[DOI] 10.1249/01.mss.0000323061.63373.e2.
View on:
Publisher’s Site
2008
Association of the ACTN3 genotype and physical functioning with age in older adults.
The journals of gerontology. Series A, Biological sciences and medical sciences.
63(11):1227-34
[PMID] 19038838.
View on:
PubMed
2008
Energy Metabolism and the Change in Body Composition During Late Life
Gerontologist.
48
2008
Energy Metabolism: Associations With Age, Fatigue and Activity
Gerontologist.
48
2008
Modulation of age-induced apoptotic signaling and cellular remodeling by exercise and calorie restriction in skeletal muscle.
Free radical biology & medicine.
44(2):160-8
[DOI] 10.1016/j.freeradbiomed.2007.05.028.
[PMID] 18191752.
2008
Physical function and self-rated health status as predictors of mortality: results from longitudinal analysis in the ilSIRENTE study.
BMC geriatrics.
8
[DOI] 10.1186/1471-2318-8-34.
[PMID] 19102751.
2008
Recovering From Mobility Limitation: a Common Practice Among Older Adults
Journal of the American Geriatrics Society.
56:S176-S177
2008
Sarcopenia =/= dynapenia.
The journals of gerontology. Series A, Biological sciences and medical sciences.
63(8):829-34
[PMID] 18772470.
View on:
PubMed
2007
Effect of prolonged unweighting of human skeletal muscle on neuromotor force control.
European journal of applied physiology.
100(1):53-62
[PMID] 17287986.
View on:
PubMed
2007
Efficacy of resistance and task-specific exercise in older adults who modify tasks of everyday life.
The journals of gerontology. Series A, Biological sciences and medical sciences.
62(6):616-23
[PMID] 17595417.
View on:
PubMed
2007
Fatigue-induced changes in phasic muscle activation patterns during dynamic trunk extension exercise.
American journal of physical medicine & rehabilitation.
86(5):373-379
[DOI] 10.1097/PHM.0b013e3180321689.
[PMID] 17303959.
2007
Knee extension strength cutpoints for maintaining mobility.
Journal of the American Geriatrics Society.
55(3):451-7
[PMID] 17341251.
View on:
PubMed
2007
Reduced physical activity increases intermuscular adipose tissue in healthy young adults.
The American journal of clinical nutrition.
85(2):377-84
[PMID] 17284732.
View on:
PubMed
2006
Adaptations in human neuromuscular function following prolonged unweighting: II. Neurological properties and motor imagery efficacy.
Journal of applied physiology (Bethesda, Md. : 1985).
101(1):264-72
[PMID] 16514003.
View on:
PubMed
2006
Daily activity energy expenditure and mortality among older adults.
JAMA.
296(2):171-9
[PMID] 16835422.
View on:
PubMed
2006
Evaluating task modification as an objective measure of functional limitation: repeatability and comparability.
The journals of gerontology. Series A, Biological sciences and medical sciences.
61(7):718-25
[PMID] 16870635.
View on:
PubMed
2006
Midlife physical activity and mobility in older age: The InCHIANTI study.
American journal of preventive medicine.
31(3):217-24
[PMID] 16905032.
View on:
PubMed
2005
Knee extensor isometric unsteadiness does not predict functional limitation in older adults.
American journal of physical medicine & rehabilitation.
84(2):112-21
[PMID] 15668559.
View on:
PubMed
2005
Misconceptions about strength exercise among older adults.
Journal of aging and physical activity.
13(4):422-33
[PMID] 16301754.
View on:
PubMed
2005
Resistance and functional training reduces knee extensor position fluctuations in functionally limited older adults.
European journal of applied physiology.
95(5-6):436-46
[PMID] 16193338.
View on:
PubMed
2005
Sex differences in muscle fatigability and activation patterns of the human quadriceps femoris.
European journal of applied physiology.
94(1-2):196-206
[PMID] 15791418.
View on:
PubMed
2004
Leg muscle activity during walking with assistive devices at varying levels of weight bearing.
Archives of physical medicine and rehabilitation.
85(9):1555-60
[PMID] 15375835.
View on:
PubMed
2003
Derecruitment of the lumbar musculature with fatiguing trunk extension exercise.
Spine.
28(3):282-7
[PMID] 12567032.
View on:
PubMed
2003
Gender differences in skeletal muscle fatigability are related to contraction type and EMG spectral compression.
Journal of applied physiology (Bethesda, Md. : 1985).
94(6):2263-72
[PMID] 12576411.
View on:
PubMed
2002
Electromyographic activity of the lumbar and hip extensors during dynamic trunk extension exercise.
Archives of physical medicine and rehabilitation.
83(11):1547-52
[PMID] 12422323.
View on:
PubMed
2002
Electromyographic activity of the trunk extensor muscles: effect of varying hip position and lumbar posture during Roman chair exercise.
Archives of physical medicine and rehabilitation.
83(11):1543-6
[PMID] 12422322.
View on:
PubMed
2002
Functionally relevant thresholds of quadriceps femoris strength.
The journals of gerontology. Series A, Biological sciences and medical sciences.
57(4):B144-52
[PMID] 11909879.
View on:
PubMed
Grants
May 2021
ACTIVE
Preventing the Calcium Channel Blocker Lower Extremity Edema Loop Diuretic Prescribing Cascade in Older Adults
Role: Other
Funding: NATL INST OF HLTH NIA
Jun 2020
ACTIVE
Coordinating Center of the Claude D. Pepper Older Americans Independence Centers
Role: Principal Investigator
Funding: WAKE FOREST UNIV
via NATL INST OF HLTH NIA
May 2020
ACTIVE
Translational Research Training on Aging and Mobility (TRAM)
Role: Principal Investigator
Funding: NATL INST OF HLTH NIA
Feb 2020
ACTIVE
Investigating Movement-evoked Pain in osteoArthritic Conditions (IMPACT): An Observational Study to Inform Culturally-Tailored Intervention Development
Role: Other
Funding: NATL INST OF HLTH NIAMS
Mar 2019
ACTIVE
Wearable Technology Infrastructure to Enhance Capacity for Real-Time, Online Assessment and Mobility (ROAMM) of Intervening Health Events in Older Adults
Role: Principal Investigator
Funding: NATL INST OF HLTH NIA
Sep 2018
ACTIVE
Multimodal imaging of brain activity to investigate walking and mobility decline in older adults
Role: Principal Investigator
Funding: NATL INST OF HLTH NIA
Aug 2018
ACTIVE
INTERmittent pneumatic ComprEssion for Disablility rEversal in PAD: the INTERCEDE Trial
Role: Faculty
Funding: NORTHWESTERN UNIV
via NATL INST OF HLTH NIA
Sep 2017
ACTIVE
The University of Florida Jacksonville Aging Studies Center (JAX-ASCENT)
Role: Co-Investigator
Funding: NATL INST OF HLTH NIA
Sep 2017
– May 2020
The acute development and persistence of frailty, comorbidity and disability in critically ill elderly patients after severe traumatic injury: induced frailty
Role: Co-Investigator
Funding: NATL INST OF HLTH NIA
Apr 2017
ACTIVE
University of Florida Claude D. Pepper Older Americans Independence Center (OAIC)
Role: Other
Funding: NATL INST OF HLTH NIA
Dec 2016
ACTIVE
MoTrPAC Consortium Coordinating Center
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAMS
Apr 2016
– Mar 2017
Claude D Pepper Older Americans Independence Center
Role: Project Manager
Funding: NATL INST OF HLTH NIA
Jan 2016
ACTIVE
ufhcc-ioa cancer-aging collaborative team grants
Role: Project Manager
Funding: UF HEALTH SHANDS HOSPITAL
Sep 2015
– Jun 2018
Muscle mass and strength cut-points associated with mobility limitation in older adults
Role: Principal Investigator
Funding: BRIGHAM AND WOMENS HOSPITAL
via NATL INST OF HLTH NIA
Sep 2015
– Mar 2018
PEAKS: Validation of mobile technologies for clinical assessment, monitoring, and intervention
Role: Principal Investigator
Funding: EVERYFIT INC
via NATL INST OF HLTH
Sep 2015
– May 2021
The ENRGISE Study
Role: Project Manager
Funding: NATL INST OF HLTH NIA
Apr 2015
– Jan 2019
Low intensity exercise intervention in peripheral artery disease
Role: Co-Investigator
Funding: NORTHWESTERN UNIV
via NATL INST OF HLTH NHLBI
Apr 2015
– Mar 2017
A pilot study to evaluate the role of brain integrity on post-hospital sarcopenia
Role: Principal Investigator
Funding: UF FOU
Apr 2015
– Mar 2016
Claude D. Pepper Older Americans Independence Center
Role: Project Manager
Funding: NATL INST OF HLTH NIA
Sep 2014
– Apr 2017
Measuring Cognitive Fatigability in Older Adults
Role: Project Manager
Funding: NATL INST OF HLTH NIA
Sep 2014
– Jan 2019
Neural Mechanisms of Dynapenia
Role: Principal Investigator
Funding: OHIO UNIV
via NATL INST OF HLTH NIA
Feb 2014
– Feb 2016
Sarcopenic transitions for predicting physical disability states
Role: Principal Investigator
Funding: SANOFI US SERVICES
Jan 2014
– Dec 2018
MtDNA variant modifiers of cardiopulmonary responsiveness to physical activity
Role: Principal Investigator
Funding: NATL INST OF HLTH NHLBI
Sep 2013
– Dec 2019
REVIVE – Resveratrol to enhance vitality and vigor in elders
Role: Co-Investigator
Funding: NATL CTR FOR COMPLEM AND INTEGRATIVE HLT
Jul 2013
– Mar 2019
Metabolic Costs of Daily Activities in Older Adults
Role: Principal Investigator
Funding: NATL INST OF HLTH NIA
Sep 2011
– Nov 2018
The LIFE Study
Role: Project Manager
Funding: NATL INST OF HLTH NIA
Jul 2006
– Dec 2020
21st Century Research & Economic Development Investment Program (REDIP)
Role: Project Manager
Funding: STATE UNIV SYS OF FL BOARD OF GOVERNORS
Education
Post-Doc in Epidemiology
2006
·
National Institute on Aging
PhD in Geriatric Exercise Physiology
2004
·
Syracuse University
Certificate of Advanced Study in Gerontology
2001
·
Syracuse University
Masters of Science in Exercise Physiology
2000
·
Syracuse University
Bachelors of Science in Biology
1997
·
Ohio University
Teaching Profile
Courses Taught
2016-2019,2021-2022
GMS6485 Population Based Research on Aging
2012-2016
PHC7980 Research for Doctoral Dissertation
2014-2015
GMS6417 Integrative Aging Physiology
2015
GMS6845 Clinical & Translational Research Practicum
2011-2013,2015
PHC7979 Advanced Research
2013
CLP7980 Research for Doctoral Dissertation
2010-2012
PHC6003 Epidemiology of Chronic Diseases and Disability
2011
PHC6905 Independent Study
2009
APK7108 Environmental Stress Exercise Physiology
2021-2022
GMS6771 Clinical Neuroscience of Aging
2021
GMS6090 Research in Medical Sciences
2021
GMS5905 Special Topics in Biomedical Sciences
2021
PHC7918 Independent Study
Contact Details
Phones:
- Business:
- (352) 273-5914
Emails:
- Business:
- tmanini@ufl.edu