Clinical Research Core

Leader: Stephen Anton,Ph.D.

Phone: 352-273-7514



Clinical Research CoreThe Clinical Research Core (RC 1) is a key resource for the UF Older Americans Independence Center (OAIC) in providing the infrastructure and investigators for conducting clinical research — randomized controlled trials and observational studies. The Clinical Research Core has four primary goals: 1) optimal selection and utilization of measures for clinical trials and observational studies 2) understanding the physiological and biomechanical mechanisms contributing to changes in walking speed, 3) in collaboration with the Biostatistics and Data Management Core, conduct secondary analyses of randomized clinical trials and observational studies to provide preliminary data to support the rationale for future clinical trials, and 4) development of behavioral and pharmacological interventions to improve physical function and quality of life of older adults.

The RC 1 offers state-of the art infrastructure and experienced personnel to support the conduction of observational studies, and Phase 2 and 3 randomized controlled trials that involve behavioral and pharmacological interventions. Senior researchers with NIH and VA funding, who also have established track records as mentors for career development, lead each one of these goals.

Specifically, the RC 1 conducts clinical research studies to assess, in conjunction with the Genomics and Biomarkers Core, the effects of behavioral interventions (exercise and weight loss) on inflammatory markers, oxidative stress, and apoptosis. Particular attention is being given to selection and standardization of physical function and disability measures.

The RC 1 supports the utilization of a uniform battery of measures: physical function, biomechanics, disability, depression, and measures of co-morbidity. State of the art and science facilities and muscle activated dynamic simulations of the gait cycle are available to investigators to understand the biomechanical mechanisms that may explain changes in walking. An experienced team of investigators supports development and standardization of behavioral interventions.