ACE Inhibition and Physical Performance in Aged Rats

Published: March 15th, 2012

Category: Pepper Projects

PI: Carter, Christy S., PhD
Funding Agency: NIH
Agency Project Number: R01AG024526
Start Date: Aug 1, 2005
End Date: Jul 31, 2011
Study Goals:

1) Determine the effect of Enalapril and Losartan vs. saline control treatment on physical performance across a portion of the lifespan of male Brown Norway x F344 rats.

2) Determine the time course of age-related changes and the effect of Enalapril vs. Losartan treatment on whole body insulin sensitivity and glucose tolerance and changes in adipose tissue and skeletal muscle physiology.

3) Relate these findings to declining physical performance.

Key Personnel:

Christy S. Carter, Ph.D.
Michael Daniels, A.B., Sc.D.
Pete Santago, II, Ph.D.