Sung Min Han, Ph.D.

Published: August 23rd, 2018

Category: Uncategorized

Profile Picture


Assistant Professor


2004 Mowry Road
Gainesville, FL 32611

PO Box 100107
Gainesville, FL 32610




Departmental Affiliation

Department of Aging and Geriatric Research, Biology of Aging Division


• 2000 B.S. Chung-Ang University, South Korea, Major: Biotechnology
• 2003 M.S. Yonsei University, South Korea, Major: Biochemistry
• 2012 Ph.D. University of Alabama at Birmingham, Birmingham, AL, USA, Major: Cell Biology

Additional Information

Sung Min began studyiing science by attending Yonsei University in South Korea where he obtained his M.S. degree in 2005. He then moved to the University of Alabama at Birmingham, U.S.A. to continue his Ph.D. training. He studied in the laboratory of Dr. Michael A. Miller. In the Miller lab, he investigated the in vivo function of VAPB/ALS8 known to cause Amyotrophic Lateral Sclerosis (ALS). After receiving his Ph.D. in Cell Biology in 2012, Sung Min moved to the Yale University School of Medicine in New Haven, where he worked as a postdoc in the laboratory of Dr. Marc Hammarlund lab. He studied the underlying mechanisms that govern axon regeneration following injury. Sung Min joined the faculty of the University of Florida College of Medicine in August, 2018. His current research goal is to identify the fundamental mechanisms that regulate axon regeneration and degeneration of adult neurons during aging and develop strategies to restore and maintain normal function of the neuromuscular system. To achieve this goal, his current researches include: 1) Investigating how neurons and muscles regulate mitochondrial dynamics in aging, in particular after axonal damage, 2) Elucidating how neurons and muscles control their gene expression during axon regeneration and aging, 3) Establishing a genetic model system of neuromuscular disorders.


• Tenure-Track Assistant Professor, Departments of Aging and Geriatric Research, Division of Biology of Aging, Institute on Aging, University of Florida, Gainesville, FL, USA. (08/2018-Present)
• Postdoctoral associate, Department of Genetics, Yale University, New Haven, CT, USA. (2013-2018)
• Postdoctoral researcher, Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL, USA. (2012-2013)
• Research Assistant, Department of Biochemistry, Yonsei University, South Korea. (2003-2005)


• Department of Genetics Research Fellowship, Yale University (2015)
• James Hudson Brown- Alexander B. Coxe Fellowship, Yale University (2014)
• Department of Genetics Research Fellowship, Yale University (2014)


Schultz J*, Lee S.J.*, Cole T., Hoang H. D., Vibbert J., Cottee P. A., Miller M. A.#, and Han S. M.# (2017) The secreted VAPB/ALS8 MSP domain patterns the adult striated muscle mitochondrial reticulum via SMN-1. Development, 2017 144(12):2187-2199. (#, co-senior author).

-Introduced in “in this issue” in the same issue of Development.

Cottee P. A., Cole T., Schultz J*, Hoang H. D., Vibbert J., Han S. M., and Miller M. A. (2017) The C. elegans VAPB/ALS8 homolog VPR-1 is a permissive signal for gonad development. Development, 44(12):2175-2186.

-Introduced in “in this issue” in the same issue of Development.

Han S. M., Baig H. B., and Hammarlund M. (2016) Mitochondria localize injured axons to support regeneration. Neuron, 92, 1308–1323.

-Previewed by PatrÓn and Zinsmaier in the same issue of Neuron.

Kosmaczewski S.*, Han S. M. *, Han B, Meyer B. I., Baig H. B., Athar W, Lin-Moore A.M., Koelle M. R., and Hammarlund M. (2015) RNA ligation in neurons by RtcB inhibits axon regeneration. Proc. Natl. Acad. Sci. USA. 112 (27), 8451-8456 (*, equal contribution).

Kosmaczewski, S., Edwards, T., Han, S. M., Meyer, B., Eckwahl, M., Peach, S., Hesselberth, J., Wolin, S. L., and Hammarlund, H. (2014) The RtcB RNA ligase is an essential component of the metazoan unfolded protein response. Embo Report: embr.201439531.

Han, S. M., Oussini H. E., Scekic-Zahirovic J., Vibbert, J., Cottee, P.A., Prasain, J., Bellen, J. H., Dupuis L., and Miller, M. A. (2013). VAPB/ALS8 MSP ligands regulate striated muscle energy metabolism critical for adult survival in Caenorhabditis elegans. PLoS Genetics 9(9): e1003738.

Han, S. M., Tsuda, H., Yang, Y., Vibbert, J., Cottee, P.A., Lee, S.J., Winek, J., Haueter, C., Prasain, J., Bellen, J. H., and Miller, M. A. (2012). Secreted VAPB/ALS8 major sperm protein domains modulate mitochondrial localization and morphology via growth cone guidance receptors. Developmental Cell 22, 348-362.

-On the cover. Previewed by Long and Vactor in the same issue of Developmental cell. Reviewed by Faculty of 1000.

Yang, Y., Han, S. M., and Miller, M. A. (2010). MSP hormonal control of the oocyte MAP kinase cascade and reactive oxygen species signaling. Developmental Biology 342, 96-107.

Han, S. M.*, Cottee, P. A.*, and Miller, M. A. (2010). Sperm and oocyte communication mechanisms controlling C. elegans fertility. Developmental Dynamics 239, 1265-1281 (Review) (*, equal contribution).

Lee, T.H., Mun, J.Y., Han, S.M., Yoon, G., Han, S.S., Koo, H.S., (2009) DIC-1 overexpression enhances respiratory activity in Caenorhabditis elegans by promoting mitochondrial cristae formation. Genes to Cells 14(3), 319-327.

Tsuda, H., Han, S. M., Yang, Y., Tong, C., Lin, Q., Mohan, K., Haueter, C., Zoghbi, A., Harati, Y., Kwan, J., Miller, M. A., and Bellen, H. J. (2008). The Amyotrophic Lateral Sclerosis 8 protein VAPB is cleaved, secreted, and acts as a ligand for Eph receptors. Cell, 133:963-77.

-On the cover, previewed by Ackerman and Cox in the same issue of Cell. Reviewed by Faculty of 1000

Han, S. M.*, Lee, T.H.*, Mun, J.Y.*, Kim, M.J., Kritikou, E.A., Lee, S.J., Han, S.S., Hengartner, M.O., Koo, H.S. (2006). Deleted in cancer 1 (DICE1) is an essential protein controlling the topology of the inner mitochondrial membrane in C. elegans. Development 133, 3597-3606 (*, equal contribution).

Lee, S.J., Yook, J.S., Han, S. M., Koo, H.S. (2004). A Werner syndrome protein homolog affects C. elegans development, growth rate, life span and sensitivity to DNA damage by acting at a DNA damage checkpoint. Development 131, 2565-75.

Lee, M.H., Han, S. M., Han, J.W., Kim, Y.M., Ahnn, J., Koo, H.S. (2003). Caenorhabditis elegans dna-2 is involved in DNA repair and is essential for germ-line development. FEBS Letter. 555, 250-6.