Christiaan Leeuwenburgh

Christiaan Leeuwenburgh, Ph.D.

Professor & Chief, Division Of Biology Of Aging

Department: MD-AGING/ GERIATRIC RES-OTHER
Business Phone: (352) 273-5735
Business Email: cleeuwen@ufl.edu

About Christiaan Leeuwenburgh

Christiaan Leeuwenburgh received his PhD from the University of Illinois, Urbana-Champagne in 1995 where his doctoral work focused on the regulation of glutathione homeostasis during chronic glutathione deficiencies and/or supplementation. He completed postdoctoral studies in Internal Medicine, Division of Geriatrics and Gerontology and Division of Atherosclerosis, Nutrition and Lipid Research at Washington University School of Medicine, Saint Louis. He became an Assistant Professor in 1998 at the University of Florida and the Director of the Biochemistry of Aging Laboratory. He was promoted to Associate Professor in 2002, Professor in 2007. In 2005 he joined the newly created Department of Aging and Geriatric Research, College of Medicine and Institute on Aging at the University of Florida. He is the Chief of the Division of Biology of Aging for the Department. Dr. Leeuwenburgh has joint faculty appointments in the Departments of Anatomy and Cell Biology, Biochemistry and Molecular Biology and a member of the department’s doctoral research faculty of the College of Medicine. Dr. Leeuwenburgh’s major research focus is to understand the molecular mechanism of oxidative stress and apoptosis with age in rodent models. The biochemistry of aging laboratory utilizes several animal models of aging. He is conducting research on the role of apoptosis in the loss of human skeletal muscle with age and it’s role in human frailty. He has participated in NIH workshops focused on the biology of aging and geriatric research of the National Institute on Aging. He has published papers in The Journal of Biological Chemistry, American Journal of Physiology and Science. He reviews regularly for numerous journals including American Journal of Physiology, Experimental Gerontology, Biogerontology, and the Journal of Gerontology and is a section editor for the Journal of Experimental Gerontology. In 2004 he received the Nathan Shock Award from the National Institute on Aging. He received the Merck Geriatric Cardiology Research Award from the Society of Geriatric Cardiology in 1999; the National Research Service Award of the NIH from the National Institute on Aging in 1997 and 1998; a Young Investigator Award from the Oxygen Society in 1996; and held an American Heart Association Pre-doctoral Fellowship from the Illinois Affiliate from 1993 through 1995. His work on assessment of oxidative damage in aging and apoptosis has been increasingly recognized and appreciated by gerontologists worldwide.

Accomplishments

Professorship Award
2019 · University of Florida
Dr. G. Lombard Kelly Lecturer
2018 · Medical College of Georgia, Augusta University
Professorship Award
2017 · University of Florida
University of Florida Research Foundation Professor
2011-2013 · University of Florida
Exemplary Teacher Award
2010 · College of Medicine, University of Florida
University of Florida Research Foundation Professor
2004-2006 · University of Florida
Nathan W. Shock Lecture Award
2004 · National Institute on Aging
American Heart Association, Young Investigator Award
2000-2002 · American Heart Association
Merck Geriatric Cardiology Research Award
1999-2000 · Society of Geriatric Cardiology
National Research Service Award, NRSA-NIH
1997-1998 · National Institute of Aging
Young Investigator Award, Oxygen Society, Intern
1996 · Soc. Free Rad. Res., Miami, FL
Honorary Fellow
1994-1995 · University of Wisconsin, Madison, WI
American Heart Association, Pre-doctoral Fellowship
1993-1995 · American Heart Association, Illinois Affiliate
The Avery Brundage Scholarship Award
1993 · University of Illinois, Urbana-Champaign, IL

Research Profile

Christiaan Leeuwenburgh’s major research focus is to understand the molecular mechanism of oxidative stress and apoptosis with age. His laboratory utilizes short and long lived animal models of aging. He is a pioneer in conducting research on the role of apoptosis in the loss of heart and skeletal muscle function with age.

Open Researcher and Contributor ID (ORCID)

0000-0003-0826-4257

Publications

2020 Arteriosclerosis Thrombosis and Vascular Biology
2019 Journal of Trauma and Acute Care Surgery
2019 Journals of Gerontology Series A-Biological Sciences and Medical Sciences
2018 Experimental Gerontology
2018 Journal of Trauma and Acute Care Surgery
2018 Journal of Trauma and Acute Care Surgery
2017 Exercise and Sport Sciences Reviews
2016 Archives of Pharmacal Research
2015 Nestle Nutrition Institute Workshop Series
2015 Medicine and Science in Sports and Exercise
2014 American Journal of Respiratory and Critical Care Medicine
2013 Journals of Gerontology Series A-Biological Sciences and Medical Sciences
2013 Experimental Gerontology
2013 Current Translational Geriatrics and Experimental Gerontology Reports
2013 International Journal of Biochemistry and Cell Biology
2012 Journals of Gerontology Series A-Biological Sciences and Medical Sciences
2012 International Journal of Molecular Sciences
2011 Journal of Aging Research
2010 Journals of Gerontology Series A-Biological Sciences and Medical Sciences
2010 Biochimica Et Biophysica Acta-General Subjects
2010 The Journals Of Gerontology. Series A, Biological Sciences And Medical Sciences
2010 Journals of Gerontology Series A-Biological Sciences and Medical Sciences
2009 Journals of Gerontology Series A-Biological Sciences and Medical Sciences
2007 American Journal of Physiology-Endocrinology and Metabolism
2007 American Journal of Physiology-Cell Physiology
2005 The American Journal of Sports Medicine
2005 American Journal of Physiology-Regulatory Integrative and Comparative Physiology
2004 American Journal of Physiology-Regulatory Integrative and Comparative Physiology
2004 American Journal of Physiology-Regulatory Integrative and Comparative Physiology
2004 American Journal of Physiology-Regulatory Integrative and Comparative Physiology
2003 American Journal of Physiology-Regulatory Integrative and Comparative Physiology
2003 Journals of Gerontology Series A-Biological Sciences and Medical Sciences
2002 Annals of the New York Academy of Sciences
2002 American Journal of Physiology-Regulatory Integrative and Comparative Physiology
2002 Annals of the New York Academy of Sciences
2002 American Journal of Physiology-Regulatory Integrative and Comparative Physiology
2001 Journals of Gerontology Series A-Biological Sciences and Medical Sciences
2001 Medical Science Sports Exercise
2000 Journal of Pediatrics

Grants

May 2020 ACTIVE
Translational Research Training on Aging and Mobility (TRAM)
NATL INST OF HLTH NIA ·
Apr 2020 ACTIVE
The Role and Mechanisms of Lipid and Lipoprotein Dysregulation in Sepsis
NATL INST OF HLTH NIGMS ·
Sep 2019 ACTIVE
Nicotinamide riboside as an Enhancer of Exercise Therapy in hypertensive older adults: The NEET Trial
NATL INST OF HLTH NIA ·
Jul 2019 ACTIVE
Molecular Biology in Burns and Trauma
NATL INST OF HLTH NIGMS ·
Aug 2018 ACTIVE
Senescence and Growth Differentiation Factors as Modifiers of Aging
MAYO CLINIC ·
Aug 2018 ACTIVE
INTERmittent pneumatic ComprEssion for Disablility rEversal in PAD: the INTERCEDE Trial
NORTHWESTERN UNIV · Principal Investigator
Jul 2018 ACTIVE
Cardiac Dysfunction in Older Sepsis Survivors
AMER HEART ASSOCIATION ·
Jul 2018 ACTIVE
Role of PFKFB3 in peripheral artery disease
AMER HEART ASSOCIATION ·
Jun 2018 ACTIVE
OR-DRPD-ROF2018: The LIPid Intensive Drug therapy for Sepsis Pilot (LIPIDS-P) Trial
UF RESEARCH ·
Jun 2018 – May 2020
PICS: A New Horizon for Surgical Critical Care
NATL INST OF HLTH NIGMS ·
Apr 2018 ACTIVE
Biobehavioral mechanisms underlying symptoms and healing outcomes in older individuals with CVLU
NATL INST OF HLTH NINR · Project Manager
Apr 2018 ACTIVE
Calf Muscle Mitochondrial Dysfunction and Impaired Autophagy in Peripheral Artery Disease
NORTHWESTERN UNIV · Principal Investigator
Apr 2018 ACTIVE
NICotinomidE riboside with and without resveratrol to improve functioning in peripheral artery disease: The NICE Trial
NORTHWESTERN UNIV · Principal Investigator
Sep 2017 ACTIVE
The University of Florida Jacksonville Aging Studies Center (JAX-ASCENT)
NATL INST OF HLTH NIA ·
Aug 2017 – Apr 2018
Resveratrol and exercise to treat functional limitations in late life
UNIV OF ALABAMA BIRMINGHAM ·
Jul 2017 ACTIVE
The effect of intermittent hemidiaphragm stimulation during surgery on mitochondrial function, single fiber contractile force and catabolic pathways in humans
NATL INST OF HLTH NIAMS ·
Jun 2017 – May 2018
PICS: A New Horizon for Surgical Critical Care
NATL INST OF HLTH NIGMS ·
Apr 2017 ACTIVE
University of Florida Claude D. Pepper Older Americans Independence Center (OAIC)
NATL INST OF HLTH NIA ·
Dec 2016 ACTIVE
UF PASS: Regulation of exercise transducers
NATL INST OF HLTH NIA · Project Manager
Dec 2016 ACTIVE
Improve PAD PERformance with METformin: The PERMET Trial
NORTHWESTERN UNIV · Principal Investigator
Dec 2016 ACTIVE
MoTrPAC Consortium Coordinating Center
NATL INST OF HLTH NIAMS ·
Sep 2016 ACTIVE
The Role of Dysfunctional HDL in Sepsis
NATL INST OF HLTH NIGMS ·
Jun 2016 – Feb 2019
COCOA to improve walking performance in Peripheral Artery Disease: the COCOA-PAD Study
NORTHWESTERN UNIV · Principal Investigator
Jun 2016 – May 2017
PICS: A New Horizon for Surgical Critical Care
NATL INST OF HLTH NIGMS · Project Manager
Apr 2016 – Mar 2017
Claude D Pepper Older Americans Independence Center
NATL INST OF HLTH NIA · Project Manager
Aug 2015 – Apr 2020
Telmisartan Plus Exercise to Improve Functioning in PAD: The TELEX Trial
NORTHWESTERN UNIV · Principal Investigator
Jun 2015 – May 2016
PICS: A New Horizon for Surgical Critical Care
NATL INST OF HLTH NIGMS · Project Manager
Apr 2015 – Mar 2016
Claude D. Pepper Older Americans Independence Center
NATL INST OF HLTH NIA · Project Manager
Apr 2015 – Jan 2019
Low intensity exercise intervention in peripheral artery disease
NORTHWESTERN UNIV · Principal Investigator
Apr 2015 ACTIVE
Hematopoietic Stem Cell Dysfunction in the Elderly after Severe Injury
NATL INST OF HLTH NIGMS ·
Jun 2014 ACTIVE
Obesity and Type-2 Diabetes: Bariatric Surgery Effects on Brain Function
NATL INST OF HLTH NIDDK ·
May 2014 – Apr 2017
RESveratrol To Improve Outcomes in older People with PAD (the RESTORE Trial)
NORTHWESTERN UNIV · Principal Investigator
Jan 2014 – Dec 2018
MtDNA variant modifiers of cardiopulmonary responsiveness to physical activity
NATL INST OF HLTH NHLBI ·
Sep 2013 – Dec 2019
REVIVE – Resveratrol to enhance vitality and vigor in elders
NATL CTR FOR COMPLEM AND INTEGRATIVE HLT ·
Apr 2012 – Mar 2017
Mitophagy: A novel target to improve liver function afte
NATL INST OF HLTH NIDDK · Project Manager
Sep 2011 – Nov 2018
The LIFE Study
NATL INST OF HLTH NIA · Project Manager
Jul 2007 – Aug 2016
Clinical and Translational Science Institute
UF RESEARCH FOU · Project Manager

Patents

Issued April 2003
Human Model to Rapidly Test the Efficacy of a variety of Anti-inflammatory and Antioxidant Compounds (Pharmaceutical or Non-pharmaceutical)
#6,541,265

Education

Post-Doc, Internal Medicine
1995-1998 · Washington University School of Medicine Instructor Geriatrics & Gerontology
Fellow, Biochemistry and Aging
1993-1995 · University of Wisconsin
PhD in Biochemistry and Aging
1990-1995 · University of Illinois
Masters of Science in Applied Physiology
1988-1990 · University of Florida
Bachelors of Science in Applied Physiology
1986-1988 · University of Florida

Contact Details

Phones:
Business:
(352) 273-5735
Emails:
Business:
cleeuwen@ufl.edu