Oxidative RNA and DNA damage to heart mitochondrial sub-populations with age and life-long calorie restrictionsPI: Leeuwenburgh, Christiaan, PhD
PI: Hofer, Tim, PhD
Funding Agency: American Heart Association
Agency Project Number: 0525346B
Start Date: Jul 1, 2005
End Date: Jun 30, 2008
The aim of this study is to investigate the role of IFM and SSM mitochondrial damage and function with age in the left ventricle of Fisher-344 rat hearts. Moreover, we will use life-long calorie restriction - a model, which extends mean and maximum lifespan, and prevents cardiomyophathy - to understand the mechanisms of myocardial aging.