Leptin Resistance: One Mechanism Underlying Age-Related Obesity.PI: Scarpace, Philip J., PhD
Funding Agency: NIA
Agency Project Number: AG026159
Start Date: Sep 1, 2004
End Date: Aug 30, 2009
The major goals of this project are: Is the leptin activated IRS-PI3K pathway impaired with leptin resistance or age-related obesity? Does the leptin mediated IRS-PI3K pathway differentially regulate the anorexic and energy expenditure responses to leptin? Is elevated leptin, independent of obesity, the primary factor in leptin resistance?
Philip J Scarpace, PhD
Nihal Tumer, PhD
Yi Zhang, PhD.