Someya, Shinichi, Ph.D.
Department of Aging and Geriatric Research
Biology of Aging Division
Institute on Aging
1600 SW Archer Road
PO Box 100143, Gainesville, FL 32610
1991, BA, Molecular and Cell Biology, University of California, Berkeley
2005, PhD, Applied Biological Chemistry, University of Tokyo
Department of Aging and Geriatric Research, Division of Biology of Aging
Department of Speech, Language and Hearing Sciences
2007 New Investigator Award in Biomedical Aging Research, 19th Annual Colloquium on Aging, UW Institute on Aging
2008 Paul Glenn Runner Up Award, The American Aging Association
2010 The 39th Annual Meeting of the American Aging Association Travel Award
2010 The 18th Annual NIA Summer Training Course in Experimental Aging Research Award
2011 The 2011 MidWinter Meeting Postdoctoral Fellow Travel Award
2014 Certificate of Appreciation, UF University Minority Mentorship Program
2014 University of Florida College of Medicine Exemplary Teacher for the 2013-2014 Year
2015 William R. Jones Outstanding Mentor Awards, Florida Education Fund
Hearing loss is the third most prevalent chronic health condition, causes individuals to understand speech poorly, and affects the quality of life in older adults. The most common type of permanent hearing loss is sensorineural hearing loss that results from damage to the cochlea, and/or to the auditory nerve pathways from the cochlea to the brain. Sensorineural hearing loss is caused by several contributing factors such as aging, ototoxic chemicals, noise exposure, and/or genetic conditions. Work in my Laboratory is focused on understanding the molecular and cellular mechanisms that underlie age-related hearing loss using various transgenic and knockout mice. A second question being studied in my laboratory is how the cochlea protects itself from endogenous and exogenous toxins throughout the lifespan. We are also interested in understanding the molecular mechanisms underlying the beneficial effects of physical activity on auditory function.
Major Teaching Responsibilities
GMS 6486 Fundamentals of Biological Aging
SPA 3032 Fundamentals of Hearing
SPA6581 Auditory Pharmacology
GMS 6417 Integrative Aging Physiology
GMS 6893 Clinical and Translational Science Institute Student Seminar
GMS 6622 Mitochondrial Biology in Aging and Disease
1. Han C, Ding D, Lopez MC, Manohar S, Zhang Y, Kim MJ, Park HJ, White K, Kim YH, Linser P, Tanokura M, Leeuwenburgh C, Baker HV, Salvi RJ, Someya S. Effects of Long-Term Exercise on Age-Related Hearing Loss in Mice. Journal of Neuroscience. 2016; 36(44):11308-11319.
2. Mankowski RT, Ahmed S, Beaver T, Dirain M, Han C, Hess P, Martin T, Smith BK, Someya S, Leeuwenburgh C, Martin AD. Intraoperative hemidiaphragm electrical stimulation reduces oxidative stress and upregulates autophagy in surgery patients undergoing mechanical ventilation: exploratory study. Journal of Translational Medicine. 2016; 14(1):305.
3. Yu H, Vikhe Patil K, Han C, Fabella B, Canlon B, Someya S, Cederroth CR. GLAST Deficiency in Mice Exacerbates Gap Detection Deficits in a Model of Salicylate-Induced Tinnitus. Frontiers in Behavioral Neuroscience. 2016; 10:158.
4. Han C, Linser P, Park HJ, Kim MJ, White K, Vann JM, Ding D, Prolla TA, Someya S. Sirt1 deficiency protects cochlear cells and delays the early onset of age-related hearing loss in C57BL/6 mice. Neurobiology of Aging. 2016; 43:58-71.
5. Anton SD, Woods AJ, Ashizawa T, Barb D, Buford TW, Carter CS, Clark DJ, Cohen RA, Corbett DB, Cruz-Almeida Y, Dotson V, Ebner N, Efron PA, Fillingim RB, Foster TC, Gundermann DM, Joseph AM, Karabetian C, Leeuwenburgh C, Manini TM, Marsiske M, Mankowski RT, Mutchie HL, Perri MG, Ranka S, Rashidi P, Sandesara B, Scarpace PJ, Sibille KT, Solberg LM, Someya S, Uphold C, Wohlgemuth S, Wu SS, Pahor M. Successful aging: Advancing the science of physical independence in older adults. Ageing Research Reviews. 2015; 24(Pt B):304-27.
6. Fischer KE, Gelfond JA, Soto VY, Han C, Someya S, Richardson A, Austad SN. Health Effects of Long-Term Rapamycin Treatment: The Impact on Mouse Health of Enteric Rapamycin Treatment from Four Months of Age throughout Life. PloS One. 2015; 10(5):e0126644.
7. Barger JL, Anderson RM, Newton MA, da Silva C, Vann JA, Pugh TD, Someya S, Prolla TA, Weindruch R. A conserved transcriptional signature of delayed aging and reduced disease vulnerability is partially mediated by SIRT3. PloS One. 2015; 10(4):e0120738.
8. Ding D, Qi W, Yu D, Jiang H, Han C, Kim MJ, Katsuno K, Hsieh YH, Miyakawa T, Salvi R, Tanokura M, Someya S. Addition of exogenous NAD+ prevents mefloquine-induced neuroaxonal and hair cell degeneration through reduction of caspase-3-mediated apoptosis in cochlear organotypic cultures. PloS One. 2013; 8(11):e79817.
9. Han C, Someya S. Maintaining good hearing: calorie restriction, Sirt3, and glutathione. Experimental Gerontology. 2013; 48(10):1091-5.
10. Yamasoba T, Lin FR, Someya S, Kashio A, Sakamoto T, Kondo K. Current concepts in age-related hearing loss: epidemiology and mechanistic pathways. Hearing Research. 2013; 303:30-8.
11. Han C, Someya S. Mouse models of age-related mitochondrial neurosensory hearing loss. Molecular and Cellular Neurosciences. 2013; 55:95-100.
12. Dalian D, Haiyan J, Yong F, Yongqi L, Salvi R, Someya S, Tanokura M. Ototoxic model of oxaliplatin and protection from nicotinamide adenine dinucleotide. Journal of Otology. 2013; 8(1):63-71.
13. Dalian D, Haiyan J, Yong F, Salvi R, Someya S, Tanokura M. Ototoxic effects of carboplatin in organotypic cultures in chinchillas and rats. Journal of Otology. 2012; 7(2):92-101.
14. Lee WH, Kumar A, Rani A, Herrera J, Xu J, Someya S, Foster TC. Influence of viral vector-mediated delivery of superoxide dismutase and catalase to the hippocampus on spatial learning and memory during aging. Antioxidants & Redox Signaling. 2012; 16(4):339-50.
15. Dalian Ding, Someya S, Jiang H, Wei–dong Qi, Yu D, Masaru T, Salvi R. Detection of apoptosis by RT–PCR array in mefloquine–induced cochlear damage. Journal of otology. 2011 June; 6(1):1-9.
16. Hallows WC, Yu W, Smith BC, Devries MK, Ellinger JJ, Someya S, Shortreed MR, Prolla T, Markley JL, Smith LM, Zhao S, Guan KL, Denu JM. Sirt3 promotes the urea cycle and fatty acid oxidation during dietary restriction. Molecular Cell. 2011; 41(2):139-49.
17. Someya S, Yu W, Hallows WC, Xu J, Vann JM, Leeuwenburgh C, Tanokura M, Denu JM, Prolla TA. Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction. Cell. 2010; 143(5):802-12.
18. Hiona A, Sanz A, Kujoth GC, Pamplona R, Seo AY, Hofer T, Someya S, Miyakawa T, Nakayama C, Samhan-Arias AK, Servais S, Barger JL, Portero-Otín M, Tanokura M, Prolla TA, Leeuwenburgh C. Mitochondrial DNA mutations induce mitochondrial dysfunction, apoptosis and sarcopenia in skeletal muscle of mitochondrial DNA mutator mice. PloS One. 2010; 5(7):e11468.
19. Someya S, Prolla TA. Mitochondrial oxidative damage and apoptosis in age-related hearing loss. Mechanisms of Ageing and Development. 2010; 131(7-8):480-6.
20. Someya S, Tanokura M, Weindruch R, Prolla TA, Yamasoba T. Effects of caloric restriction on age-related hearing loss in rodents and rhesus monkeys. Current Aging Science. 2010; 3(1):20-5.
21. Someya S, Xu J, Kondo K, Ding D, Salvi RJ, Yamasoba T, Rabinovitch PS, Weindruch R, Leeuwenburgh C, Tanokura M, Prolla TA. Age-related hearing loss in C57BL/6J mice is mediated by Bak-dependent mitochondrial apoptosis. Proceedings of the National Academy of Sciences of the United States of America. 2009; 106(46):19432-7.
22. Someya S, Yamasoba T, Kujoth GC, Pugh TD, Weindruch R, Tanokura M, Prolla TA. The role of mtDNA mutations in the pathogenesis of age-related hearing loss in mice carrying a mutator DNA polymerase gamma. Neurobiology of Aging. 2008; 29(7):1080-92.
23. Someya S, Yamasoba T, Prolla TA, Tanokura M. Genes encoding mitochondrial respiratory chain components are profoundly down-regulated with aging in the cochlea of DBA/2J mice. Brain Research. 2007; 1182:26-33.
24. Someya S, Yamasoba T, Weindruch R, Prolla TA, Tanokura M. Caloric restriction suppresses apoptotic cell death in the mammalian cochlea and leads to prevention of presbycusis. Neurobiology of Aging. 2007; 28(10):1613-22.
25. Yamasoba T, Someya S, Yamada C, Weindruch R, Prolla TA, Tanokura M. Role of mitochondrial dysfunction and mitochondrial DNA mutations in age-related hearing loss. Hearing research. 2007; 226(1-2):185-93.
26. Yamasoba T, Someya S, Tanokura M. Mechanisms of presbycusis and its prevention by caloric restriction. Otology Japan. 2006; 16(2):131-134.
27. Kujoth GC, Hiona A, Pugh TD, Someya S, Panzer K, Wohlgemuth SE, Hofer T, Seo AY, Sullivan R, Jobling WA, Morrow JD, Van Remmen H, Sedivy JM, Yamasoba T, Tanokura M, Weindruch R, Leeuwenburgh C, Prolla TA. Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging. Science. 2005; 309(5733):481-4.
28. Suzuki T, Someya S, Hu F, Tanokura M. Comparative study of catechin composition in five Japanese persimmons (Diospyros kaki). Food Chemistry. 2005; 93(1):149-152.
29. Someya S, Yoshiki Y, Okubo K. Antioxidant compounds from bananas (Musa Cavendish). Food Chemistry. 2002 November; 79(3):351-354.
30. Iida T, Yoshiki Y, Someya S, Okubo K Generation of reactive oxygen species and photon emission from a browned product. Bioscience, Biotechnology, and Biochemistry. 2002; 66(8):1641-5.
Books and Book Chapters
31. Kim MJ, White K, Walker L, Han C, Someya S. Age-related Hearing Loss: Biochemical Pathways and Molecular Targets in Free Radicals in ENT pathology. Miller J, LePrell CG, Rybak L, editors. USA: Humana Press, 2015; Chapter 13, p.273-288. 502p.
32. Han Chul, Someya S. Update on the Free Radical Theory of Aging: The Role of Oxidative Stress in Age-related Hearing Loss in Systems Biology of Free Radicals and Anti-oxidants. Laher Issy, editor. Berlin Heidelberg, Germany: Springer-Verlag. 2014; Chapter 158, p.3581-98. 4108 p.
33. Someya S, Prolla TA., Tanokura M. Effects of Nutraceuticals Antioxidants on Age-related Hearing Loss in Biotechnology in Functional Foods and Nutraceuticals. Bagchi D, Lau FC, Ghosh DK, editors. Boca Raton, FL, USA: CRC Press; Chapter 8, 2010.; p.113-124. 591p.